دورية أكاديمية
Neonatology / Assessment of comfort during less invasive surfactant administration in very preterm infants: a multicenter study
| العنوان: | Neonatology / Assessment of comfort during less invasive surfactant administration in very preterm infants: a multicenter study |
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| المؤلفون: | Klebermass-Schrehof, Katrin, Pichler, Karin, Kuehne, Benjamin, Dekker, Janneke, Stummer, Sophie, Giordano, Vito, Berger, Angelika, Kribs, Angela |
| بيانات النشر: | Karger |
| سنة النشر: | 2023 |
| المجموعة: | MedUni Vienna ePub (Medzinische Universität Wien) |
| مصطلحات موضوعية: | Preterm infants, Comfort, Less invasive surfactant administration, Respiratory distress syndrome |
| جغرافية الموضوع: | UMW:17678 |
| الوصف: | Introduction: This study was set up to investigate if and to what extent non-pharmacological analgesia is able to provide comfort to very preterm infants (VPI) during less invasive surfactant administration (LISA). Methods: This was a prospective non-randomized multicenter observational study performed in level IV NICUs. Inborn VPI with a gestational age between 22 0/7 and 31 6/7 weeks, signs of respiratory distress syndrome, and the need for surfactant replacement were included. Non-pharmacological analgesia was performed in all infants during LISA. In case of failure of the first LISA attempt, additional analgosedation could be administered. COMFORTneo scores during LISA were assessed. Results: 113 VPI with a mean gestational age of 27 weeks (+/− 2.3 weeks) and mean birth weight of 946 g (+/− 33 g) were included. LISA was successful at the first laryngoscopy attempt in 81%. COMFORTneo scores were highest during laryngoscopy. At this time point, non-pharmacological analgesia provided adequate comfort in 61% of the infants. 74.4% of lower gestational aged infants (i.e., 220–266 weeks) were within the comfort zone during laryngoscopy compared to 51.6% of higher gestational aged infants (i.e., 270–320 weeks) (p = 0.016). The time point of surfactant administration did not influence the COMFORTneo scores during the LISA procedure. Conclusion: Non-pharmacological analgesia provided comfort in as much as 61% of the included VPI during LISA. Further research is needed to both develop strategies to identify infants who, despite receiving non-pharmacological analgesia, are at high risk for experiencing discomfort during LISA and define patient-tailored dosage and choice of analgosedative drugs. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 1661-7819 |
| العلاقة: | vignette : https://repositorium.meduniwien.ac.at/titlepage/urn/urn:nbn:at:at-ubmuw:3-79799/128Test; urn:nbn:at:at-ubmuw:3-79799; https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-79799Test; local:99147681329103331; system:AC16945919 |
| DOI: | 10.1159/000530333 |
| الإتاحة: | https://doi.org/10.1159/000530333Test https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-79799Test |
| حقوق: | cc-by-nc_4 |
| رقم الانضمام: | edsbas.D1CAB4CB |
| قاعدة البيانات: | BASE |
| تدمد: | 16617819 |
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| DOI: | 10.1159/000530333 |