التفاصيل البيبلوغرافية
| العنوان: |
Inflammation and Oxidative Stress in Diabetic Kidney Disease: The Targets for SGLT2 Inhibitors and GLP-1 Receptor Agonists |
| المؤلفون: |
Agata Winiarska, Monika Knysak, Katarzyna Nabrdalik, Janusz Gumprecht, Tomasz Stompór |
| المصدر: |
International Journal of Molecular Sciences; Volume 22; Issue 19; Pages: 10822 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
type 2 diabetes, sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor antagonists, diabetic kidney disease, oxidative stress, inflammation, autophagy, sirtuin 1, cytokines, macrophages |
| جغرافية الموضوع: |
agris |
| الوصف: |
The incidence of type 2 diabetes (T2D) has been increasing worldwide, and diabetic kidney disease (DKD) remains one of the leading long-term complications of T2D. Several lines of evidence indicate that glucose-lowering agents prevent the onset and progression of DKD in its early stages but are of limited efficacy in later stages of DKD. However, sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor (GLP-1R) agonists were shown to exert nephroprotective effects in patients with established DKD, i.e., those who had a reduced glomerular filtration rate. These effects cannot be solely attributed to the improved metabolic control of diabetes. In our review, we attempted to discuss the interactions of both groups of agents with inflammation and oxidative stress—the key pathways contributing to organ damage in the course of diabetes. SGLT2i and GLP-1R agonists attenuate inflammation and oxidative stress in experimental in vitro and in vivo models of DKD in several ways. In addition, we have described experiments showing the same protective mechanisms as found in DKD in non-diabetic kidney injury models as well as in some tissues and organs other than the kidney. The interaction between both drug groups, inflammation and oxidative stress appears to have a universal mechanism of organ protection in diabetes and other diseases. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Molecular Pharmacology; https://dx.doi.org/10.3390/ijms221910822Test |
| DOI: |
10.3390/ijms221910822 |
| الإتاحة: |
https://doi.org/10.3390/ijms221910822Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.D19AEE9D |
| قاعدة البيانات: |
BASE |
