دورية أكاديمية
Economic evaluation of multiplex ligation-dependent probe amplification and karyotyping in prenatal diagnosis: a cost-minimization analysis
| العنوان: | Economic evaluation of multiplex ligation-dependent probe amplification and karyotyping in prenatal diagnosis: a cost-minimization analysis |
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| المؤلفون: | Boormans, EMA, Birnie, Erwin, Hoffer, MJV, Macville, MVE, Galjaard, Robert-Jan, Schuring-Blom, GH, Bhola, SL, Huijsdens, K, Smits, A, van Lith, JMM |
| المصدر: | Boormans , EMA , Birnie , E , Hoffer , MJV , Macville , MVE , Galjaard , R-J , Schuring-Blom , GH , Bhola , SL , Huijsdens , K , Smits , A & van Lith , JMM 2012 , ' Economic evaluation of multiplex ligation-dependent probe amplification and karyotyping in prenatal diagnosis: a cost-minimization analysis ' , Archives of Gynecology and Obstetrics , vol. 285 , no. 1 , pp. 67-75 . https://doi.org/10.1007/s00404-011-1921-yTest |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, SDG 3 - Good Health and Well-being |
| الوصف: | Purpose To assess the cost-effectiveness of Multiplex Ligation-dependent Probe Amplification (MLPA, P095 kit) compared to karyotyping. Methods A cost-minimization analysis alongside a nationwide prospective clinical study of 4,585 women undergoing amniocentesis on behalf of their age (>= 36 years), an increased risk following first trimester prenatal screening or parental anxiety. Results Diagnostic accuracy of MLPA (P095 kit) was comparable to karyotyping (1.0 95% CI 0.999-1.0). Health-related quality of life did not differ between the strategies summary physical health: mean difference 0.31, p = 0.82; summary mental health: mean difference 1.91, p = 0.22). Short-term costs were lower for MLPA: mean difference (sic)315.68 (bootstrap 95% CI (sic)315.63-315.74; -44.4%). The long-term costs were slightly higher for MLPA: mean difference (sic)76.42 (bootstrap 95% CI (sic)71. Conclusion From an economic perspective, MLPA is the preferred prenatal diagnostic strategy in women who undergo amniocentesis on behalf of their age, following prenatal screening or parental anxiety. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| DOI: | 10.1007/s00404-011-1921-y |
| الإتاحة: | https://doi.org/10.1007/s00404-011-1921-yTest https://pure.eur.nl/en/publications/2f845823-4091-4635-8621-13ef360df7a0Test https://pure.eur.nl/ws/files/47451754/00210.pdfTest http://hdl.handle.net/1765/26376Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D136DD1D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00404-011-1921-y |
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