دورية أكاديمية
The Class I HDAC Inhibitor, MS-275, Prevents Oxaliplatin-Induced Chronic Neuropathy and Potentiates Its Antiproliferative Activity in Mice
| العنوان: | The Class I HDAC Inhibitor, MS-275, Prevents Oxaliplatin-Induced Chronic Neuropathy and Potentiates Its Antiproliferative Activity in Mice |
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| المؤلفون: | Lamoine, Sylvain, Cumenal, Mélissa, Barriere, David, Pereira, Vanessa, Fereyrolles, Mathilde, Prival, Laëtitia, Barbier, Julie, Boudieu, Ludivine, Brasset, Emilie, Bertin, Benjamin, Renaud, Yoan, Miot-Noirault, Elisabeth, Civiale, Marie-Ange, Balayssac, David, Aissouni, Youssef, Eschalier, Alain, Busserolles, Jérôme |
| المساهمون: | Neuro-Dol (Neuro-Dol), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), CHU Clermont-Ferrand, Génétique, Reproduction et Développement (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Imagerie Moléculaire et Stratégies Théranostiques (IMoST), AutomédiCation aCcompagnement Pluriprofessionnel PatienT (ACCePPT), Université Clermont Auvergne (UCA), Direction de la recherche clinique et de l’innovation CHU Clermont-Ferrand (DRCI), Institut Analgesia |
| المصدر: | ISSN: 1661-6596. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2022 |
| المجموعة: | HAL Clermont Auvergne (Université Blaise Pascal Clermont-Ferrand / Université d'Auvergne) |
| مصطلحات موضوعية: | APCMin/+ mice, CT26 cells, HT29 cells, MS-275, T84 cells, colorectal cancer, histone deacetylase inhibitor, orthotopic model of colorectal cancer, oxaliplatin, peripheral neuropathy, MESH: Antineoplastic Agents / pharmacology, MESH: Apoptosis / drug effects, MESH: Neurotoxicity Syndromes / drug therapy, MESH: Oxaliplatin / pharmacology, MESH: Pyridines / pharmacology, MESH: Benzamides / pharmacology, MESH: Cell Death / drug effects, MESH: Cell Line, Tumor, MESH: Cell Proliferation / drug effects, MESH: HT29 Cells, MESH: Histone Deacetylase Inhibitors / pharmacology, MESH: Mice, Inbred BALB C, Inbred C57BL, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; Oxaliplatin, the first-line chemotherapeutic agent against colorectal cancer (CRC), induces peripheral neuropathies, which can lead to dose limitation and treatment discontinuation. Downregulation of potassium channels, which involves histone deacetylase (HDAC) activity, has been identified as an important tuner of acute oxaliplatin-induced hypersensitivity. MS-275, a class I histone deacetylase inhibitor (HDACi), prevents acute oxaliplatin-induced peripheral neuropathy (OIPN). Moreover, MS-275 exerts anti-tumor activity in several types of cancers, including CRC. We thus hypothesized that MS-275 could exert both a preventive effect against OIPN and potentially a synergistic effect combined with oxaliplatin against CRC development. We first used RNAseq to assess transcriptional changes occurring in DRG neurons from mice treated by repeated injection of oxaliplatin. Moreover, we assessed the effects of MS-275 on chronic oxaliplatin-induced peripheral neuropathy development in vivo on APCMin/+ mice and on cancer progression when combined with oxaliplatin, both in vivo on APCMin/+ mice and in a mouse model of an orthotopic allograft of the CT26 cell line as well as in vitro in T84 and HT29 human CRC cell lines. We found 741 differentially expressed genes (DEGs) between oxaliplatin- and vehicle-treated animals. While acute OIPN is known as a channelopathy involving HDAC activity, chronic OIPN exerts weak ion channel transcriptional changes and no HDAC expression changes in peripheral neurons from OIPN mice. However, MS-275 prevents the development of sensory neuropathic symptoms induced by repeated oxaliplatin administration in APCMin/+ mice. Moreover, combined with oxaliplatin, MS-275 also exerts synergistic antiproliferative and increased survival effects in CT26-bearing mice. Consistently, combined drug associations exert synergic apoptotic and cell death effects in both T84 and HT29 human CRC cell lines. Our results strongly suggest combining oxaliplatin and MS-275 administration in CRC ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35008525; hal-03703118; https://uca.hal.science/hal-03703118Test; https://uca.hal.science/hal-03703118/documentTest; https://uca.hal.science/hal-03703118/file/ijms-23-00098-v2.pdfTest; PUBMED: 35008525; PUBMEDCENTRAL: PMC8745279 |
| DOI: | 10.3390/ijms23010098 |
| الإتاحة: | https://doi.org/10.3390/ijms23010098Test https://uca.hal.science/hal-03703118Test https://uca.hal.science/hal-03703118/documentTest https://uca.hal.science/hal-03703118/file/ijms-23-00098-v2.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.D0F63844 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms23010098 |
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