التفاصيل البيبلوغرافية
| العنوان: |
Causal relationship between multiple sclerosis and cortical structure: a Mendelian randomization study |
| المؤلفون: |
Sun, Dongren, Wang, Rui, Du, Qin, Zhang, Ying, Chen, Hongxi, Shi, Ziyan, Wang, Xiaofei, Zhou, Hongyu |
| المساهمون: |
the Department of Science and Technology of Sichuan Province, the 1·3·5 project for disciplines of excellence – Clinical Research Incubation Project, West China Hospital, Sichuan University, the National Natural Science Foundation of China, the Natural Science Foundation of Sichuan Province |
| المصدر: |
Journal of Translational Medicine ; volume 22, issue 1 ; ISSN 1479-5876 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
General Biochemistry, Genetics and Molecular Biology, General Medicine |
| الوصف: |
Background Observational studies have suggested an association between multiple sclerosis (MS) and cortical structure, but the results have been inconsistent. Objective We used two-sample Mendelian randomization (MR) to assess the causal relationship between MS and cortical structure. Methods MS data as the exposure trait, including 14,498 cases and 24,091 controls, were obtained from the International Multiple Sclerosis Genetics Consortium. Genome-wide association study (GWAS) data for cortical surface area (SAw/nw) and thickness (THw/nw) in 51,665 individuals of European ancestry were obtained from the ENIGMA Consortium. The inverse-variance weighted (IVW) method was used as the primary analysis for MR. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy. Enrichment analysis was performed on MR analyses filtered by sensitivity analysis. Results After IVW and sensitivity analysis filtering, only six surviving MR results provided suggestive evidence supporting a causal relationship between MS and cortical structure, including lingual SAw ( p = .0342, beta (se) = 5.7127 (2.6969)), parahippocampal SAw ( p = .0224, beta (se) = 1.5577 (0.6822)), rostral middle frontal SAw ( p = .0154, beta (se) = − 9.0301 (3.7281)), cuneus THw ( p = .0418, beta (se) = − 0.0020 (0.0010)), lateral orbitofrontal THw ( p = .0281, beta (se) = 0.0025 (0.0010)), and lateral orbitofrontal THnw ( p = .0417, beta (se) = 0.0029 (0.0014)). Enrichment analysis suggested that leukocyte cell-related pathways, JAK-STAT signaling pathway, NF-kappa B signaling pathway, cytokine-cytokine receptor interaction, and prolactin signaling pathway may be involved in the effect of MS on cortical morphology. Conclusion Our results provide evidence supporting a causal relationship between MS and cortical structure. Enrichment analysis suggests that the pathways mediating brain morphology abnormalities in MS patients are mainly related to immune and inflammation-driven pathways. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1186/s12967-024-04892-7 |
| DOI: |
10.1186/s12967-024-04892-7.pdf |
| DOI: |
10.1186/s12967-024-04892-7/fulltext.html |
| الإتاحة: |
https://doi.org/10.1186/s12967-024-04892-7Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.D0B086C8 |
| قاعدة البيانات: |
BASE |
