دورية أكاديمية
Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy
| العنوان: | Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy |
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| المؤلفون: | Kovacs, Gabor G., Ferrer, Isidro (Ferrer Abizanda), Grinberg, Lea T., Alafuzoff, Irina, Attems, Johannes, Budka, Herbert, Cairns, Nigel J., Crary, John F., Duyckaerts, Charles, Ghetti, Bernardino, Halliday, Glenda M., Ironside, James W., Love, Seth, Mackenzie, Ian R., Muñoz, David G., Murray, Melissa E., Nelson, Peter T., Takahashi, Hitoshi, Trojanowski, John Q., Ansorge, Olaf, Arzberger, Thomas, Baborie, Atik, Beach, Thomas G., Bigio, Eileen H., Bodi, Istvan, Dugger, Brittany N., Feany, Mel, Gelpi, Ellen, Gentleman, Stephen M., Giaccone, Giorgio, Hatanpaa, Kimmo J., Heale, Richard, Hof, Patrick R., Hofer, Monika, Hortobágyi, Tibor, Jellinger, Kurt, Jicha, Gregory A., Ince, Paul, Kofler, Julia, Kövari, Enikö, Bieniek, Kevin F., Kril, Jillian J., Mann, David M., Matej, Radoslav, McKee, Ann C., Milenkovic, Ivan, Montine, Thomas J., Murayama, Shigeo, Lee, Edward B., Rodriguez, Roberta D., Rozemüller, Annemieke, Schneider, Julie A., Schultz, Christian, Seeley, William W., Seilhean, Danielle, Smith, Colin, Tagliavini, Fabrizio, Takao, Masaki, Thal, Dietmar Rudolf, Toledo, Jon B., Tolnay, Markus, Troncoso, Juan C., Vinters, Harry V., Weis, Serge, Wharton, Stephen B., White III, Charles L., McLean, Catriona, Rahimi, Jasmin, Wisniewski, Thomas, Woulfe, John M., Yamada, Masahito, Dickson, Dennis W. |
| المصدر: | Articles publicats en revistes (Patologia i Terapèutica Experimental) |
| بيانات النشر: | Springer Verlag |
| سنة النشر: | 2016 |
| المجموعة: | Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: | Envelliment cerebral, Astròcits, Malalties neurodegeneratives, Aging brain, Astrocytes, Neurodegenerative Diseases |
| الوصف: | Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of astroglial tau pathology in the aged brain, ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 16 p.; application/pdf |
| اللغة: | English |
| تدمد: | 0001-6322 |
| العلاقة: | Versió postprint del document publicat a: https://doi.org/10.1007/s00401-015-1509-xTest; Acta Neuropathologica, 2016, vol. 131, num. 1, p. 87-102; https://doi.org/10.1007/s00401-015-1509-xTest; info:eu-repo/grantAgreement/EC/FP7/278486/EU//DEVELAGE; http://hdl.handle.net/2445/127180Test; 667081 |
| الإتاحة: | https://doi.org/10.1007/s00401-015-1509-xTest http://hdl.handle.net/2445/127180Test |
| حقوق: | (c) Springer Verlag, 2016 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D05F5F21 |
| قاعدة البيانات: | BASE |
| تدمد: | 00016322 |
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