التفاصيل البيبلوغرافية
| العنوان: |
Extinction and reinstatement of an operant responding maintained by food in different models of obesity |
| المؤلفون: |
Burokas, Aurelijus, Martín‐García, Elena, Espinosa‐Carrasco, Jose, Erb, Ionas, McDonald, Jerome, Notredame, Cedric, Dierssen, Mara, Maldonado, Rafael |
| المساهمون: |
Centre for Industrial Technological Development, Ministerio de Economía y Competitividad, Fondation Jérôme Lejeune, Agència de Gestió d’Ajuts Universitaris i de Recerca, Seventh Framework Programme |
| المصدر: |
Addiction Biology ; volume 23, issue 2, page 544-555 ; ISSN 1355-6215 1369-1600 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2017 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
A major problem in treating obesity is the high rate of relapse to abnormal food‐taking habits after maintaining an energy balanced diet. Alterations of eating behavior such as compulsive‐like behavior and lack of self‐control over food intake play a critical role in relapse. In this study, we used an operant paradigm of food‐seeking behavior on two different diet‐induced obesity models, a free‐choice chocolate‐mixture diet and a high‐fat diet with face validity for a rapid development of obesity or for unhealthy food regularly consumed in our societies. A reduced operant performance and motivation for the hedonic value of palatable chocolate pellets was revealed in both obesity mouse models. However, only mice exposed to high‐fat diet showed an increased compulsive‐like behavior in the absence of the reinforcer further characterized by impaired operant learning, enhanced impulsivity and intensified inflexibility. We used principal component analysis to globally identify the specific behaviors responsible for the differences among diet groups. Learning impairment and inflexible behaviors contributed to a first principal component, explaining the largest proportion of the variance in the high‐fat diet mice phenotype. Reinforcement, impulsion and compulsion were the main contributors to the second principal component explaining the differences in the chocolate‐mixture mice behavioral phenotype. These behaviors were not exclusive of chocolate group because some high‐fat individuals showed similar values on this component. These data indicate that extended access to hypercaloric diets differentially modifies operant behavior learning, behavioral flexibility, impulsive‐like and compulsive‐like behavior, and these effects were dependent on the exposure to each specific diet. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/adb.12597 |
| الإتاحة: |
https://doi.org/10.1111/adb.12597Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.D05AF290 |
| قاعدة البيانات: |
BASE |
