دورية أكاديمية
Development and validation of combined symptom-medication scores for allergic rhinitis*
| العنوان: | Development and validation of combined symptom-medication scores for allergic rhinitis* |
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| المؤلفون: | Sousa-Pinto, Bernardo, Azevedo, Luis Filipe, Jutel, Marek, Agache, Ioana, Canonica, G. Walter, Czarlewski, Wienczyslawa, Papadopoulos, Nikolaos G., Bergmann, Karl-Christian, Devillier, Philippe, Laune, Daniel, Klimek, Ludger, Anto, Aram, Anto, Josep M., Eklund, Patrik, Almeida, Rute, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Brough, Helen A., Brussino, Luisa, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Chivato, Tomas, Costa, Elisio M., Cruz, Alvaro A., Dramburg, Stephanie, Durham, Stephen R., De Feo, Giulia, van Wijk, Roy Gerth, Fokkens, Wystke J., Gemicioglu, Bilun, Haahtela, Tari, Illario, Maddalena, Carlos Ivancevich, Juan, Kvedariene, Violeta, Kuna, Piotr, Larenas-Linnemann, Desiree E., Makris, Michael, Mathieu-Dupas, Eve, Melen, Erik, Morais-Almeida, Mario, Moesges, Ralph, Mullol, Joaquim, Nadeau, Kari C., Nhan Pham-Thi, O'Hehir, Robyn, Regateiro, Frederico S., Reitsma, Sietze, Samolinski, Boleslaw, Sheikh, Aziz, Stellato, Cristiana, Todo-Bom, Ana, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Arunas, Ventura, Maria Teresa, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Vries, Govert, Eerd, Michiel, Zieglmayer, Petra, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao Almeida, Bousquet, Jean |
| المساهمون: | HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, University of Helsinki |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: | medication score, quality-of-life, rhinitis, symptom score, work, WORK PRODUCTIVITY, IMMUNOTHERAPY, QUESTIONNAIRE, IMPAIRMENT, RESPONSIVENESS, RELIABILITY, VALIDITY, TRIALS, ASTHMA, EQ-5D, General medicine, internal medicine and other clinical medicine |
| الوصف: | Background Validated combined symptom-medication scores (CSMSs) are needed to investigate the effects of allergic rhinitis treatments. This study aimed to use real-life data from the MASK-air(R) app to generate and validate hypothesis- and data-driven CSMSs. Methods We used MASK-air(R) data to assess the concurrent validity, test-retest reliability and responsiveness of one hypothesis-driven CSMS (modified CSMS: mCSMS), one mixed hypothesis- and data-driven score (mixed score), and several data-driven CSMSs. The latter were generated with MASK-air(R) data following cluster analysis and regression models or factor analysis. These CSMSs were compared with scales measuring (i) the impact of rhinitis on work productivity (visual analogue scale [VAS] of work of MASK-air(R), and Work Productivity and Activity Impairment: Allergy Specific [WPAI-AS]), (ii) quality-of-life (EQ-5D VAS) and (iii) control of allergic diseases (Control of Allergic Rhinitis and Asthma Test [CARAT]). Results We assessed 317,176 days of MASK-air(R) use from 17,780 users aged 16-90 years, in 25 countries. The mCSMS and the factor analyses-based CSMSs displayed poorer validity and responsiveness compared to the remaining CSMSs. The latter displayed moderate-to-strong correlations with the tested comparators, high test-retest reliability and moderate-to-large responsiveness. Among data-driven CSMSs, a better performance was observed for cluster analyses-based CSMSs. High accuracy (capacity of discriminating different levels of rhinitis control) was observed for the latter (AUC-ROC = 0.904) and for the mixed CSMS (AUC-ROC = 0.820). Conclusion The mixed CSMS and the cluster-based CSMSs presented medium-high validity, reliability and accuracy, rendering them as candidates for primary endpoints in future rhinitis trials. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | This study was funded by ARIA. MASK-air (R) has been supported by EU grants (EU Structural and Development grant, POLLAR: EIT Health and Structural and Development Funds) and educational grants from Mylan-Viatris, ALK, GSK, Novartis and Uriach.; Sousa-Pinto , B , Azevedo , L F , Jutel , M , Agache , I , Canonica , G W , Czarlewski , W , Papadopoulos , N G , Bergmann , K-C , Devillier , P , Laune , D , Klimek , L , Anto , A , Anto , J M , Eklund , P , Almeida , R , Bedbrook , A , Bosnic-Anticevich , S , Brough , H A , Brussino , L , Cardona , V , Casale , T , Cecchi , L , Charpin , D , Chivato , T , Costa , E M , Cruz , A A , Dramburg , S , Durham , S R , De Feo , G , van Wijk , R G , Fokkens , W J , Gemicioglu , B , Haahtela , T , Illario , M , Carlos Ivancevich , J , Kvedariene , V , Kuna , P , Larenas-Linnemann , D E , Makris , M , Mathieu-Dupas , E , Melen , E , Morais-Almeida , M , Moesges , R , Mullol , J , Nadeau , K C , Nhan Pham-Thi , O'Hehir , R , Regateiro , F S , Reitsma , S , Samolinski , B , Sheikh , A , Stellato , C , Todo-Bom , A , Tomazic , P V , Toppila-Salmi , S , Valero , A , Valiulis , A , Ventura , M T , Wallace , D , Waserman , S , Yorgancioglu , A , Vries , G , Eerd , M , Zieglmayer , P , Zuberbier , T , Pfaar , O , Fonseca , J A & Bousquet , J 2022 , ' Development and validation of combined symptom-medication scores for allergic rhinitis* ' , Allergy : European journal of allergy and clinical immunology , vol. 77 , no. 7 , pp. 2147-2162 . https://doi.org/10.1111/all.15199Test; ORCID: /0000-0003-0890-6686/work/117947148; http://hdl.handle.net/10138/347360Test; d24a325d-ba38-481c-99bf-3fb0c4425b0a; 000742656800001 |
| الإتاحة: | http://hdl.handle.net/10138/347360Test |
| حقوق: | cc_by_nc_nd ; info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: | edsbas.D03758A5 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |