دورية أكاديمية
The commensal bacterium Lactiplantibacillus plantarum imprints innate memory-like responses in mononuclear phagocytes
| العنوان: | The commensal bacterium Lactiplantibacillus plantarum imprints innate memory-like responses in mononuclear phagocytes |
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| المؤلفون: | Pellón Rodríguez, Aize, Barriales, Diego, Peña Cearra, Ainize, Castelo Careaga, Janire, Palacios, Ainhoa, López, Nerea, Atondo Gondra, Estibaliz, Pascual Itoiz, Miguel Ángel, Martín Ruiz, Itziar, Sampedro, Leticia, González López, Monika, Bárcena, Laura, Martín Mateos, Teresa, Landete, José María, Prados Rosales, Rafael, Plaza Vinuesa, Laura, Muñoz, Rosario, De las Rivas, Blanca, Rodríguez, Juan Miguel, Berra Ramírez, Miren Edurne, Aransay Bañares, Ana María, Abecia Aliende, Leticia, Lavín, José L., Rodríguez López, Héctor, Anguita Castillo, Juan de Dios |
| بيانات النشر: | Taylor and Francis |
| سنة النشر: | 2021 |
| المجموعة: | ADDI: Repositorio Institucional de la Universidad del País Vasco / Euskal Herriko Unibertsitatea (UPV/EHU - Basque Country University) |
| مصطلحات موضوعية: | lactiplantibacillus plantarum, lactobacillus, monocytes, macrophages, innate immune memory, trained immunity, microbiota, immunometabolism, host, RNA, mechanisms, tolerance |
| الوصف: | Gut microbiota is a constant source of antigens and stimuli to which the resident immune system has developed tolerance. However, the mechanisms by which mononuclear phagocytes, specifically monocytes/macrophages, cope with these usually pro-inflammatory signals are poorly understood. Here, we show that innate immune memory promotes anti-inflammatory homeostasis, using as model strains of the commensal bacterium Lactiplantibacillus plantarum. Priming of monocytes/macrophages with bacteria, especially in its live form, enhances bacterial intracellular survival and decreases the release of pro-inflammatory signals to the environment, with lower production of TNF and higher levels of IL-10. Analysis of the transcriptomic landscape of these cells shows downregulation of pathways associated with the production of reactive oxygen species (ROS) and the release of cytokines, chemokines and antimicrobial peptides. Indeed, the induction of ROS prevents memory-induced bacterial survival. In addition, there is a dysregulation in gene expression of several metabolic pathways leading to decreased glycolytic and respiratory rates in memory cells. These data support commensal microbe-specific metabolic changes in innate immune memory cells that might contribute to homeostasis in the gut. ; This work was supported by the Ministerio de Ciencia e Innovacion [BFU2016-76872-R]; Ministerio de Ciencia e Innovacion [AGL2017-86757-R]; Ministerio de Ciencia e Innovacion [SEV-2016-0644]; Ministerio de Ciencia e Innovacion [SAF2015-73549-JIN]; Ministerio de Ciencia e Innovacion [RTI2018-096494-B-100] |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1949-0976 1949-0984 |
| العلاقة: | info:eu-repo/grantAgreement/MICINN/BFU2016-76872-R; info:eu-repo/grantAgreement/MICINN/AGL2017-86757-R; info:eu-repo/grantAgreement/MICINN/SEV-2016-0644; info:eu-repo/grantAgreement/MICINN/SAF2015-73549-JIN; info:eu-repo/grantAgreement/MICINN/RTI2018-096494-B-100; Gut Microbes 13(1) : (2021) // Article ID 1939598; http://hdl.handle.net/10810/52852Test |
| DOI: | 10.1080/19490976.2021.1939598 |
| الإتاحة: | https://doi.org/10.1080/19490976.2021.1939598Test http://hdl.handle.net/10810/52852Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/3.0/esTest/ ; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) ; Atribución 3.0 España |
| رقم الانضمام: | edsbas.CFC9656C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19490976 19490984 |
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| DOI: | 10.1080/19490976.2021.1939598 |