دورية أكاديمية
Role of membrane estrogen receptor alpha (ERα) in the rapid regulation of male sexual behavior.
| العنوان: | Role of membrane estrogen receptor alpha (ERα) in the rapid regulation of male sexual behavior. |
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| المؤلفون: | de Bournonville, Catherine, Lemoine, Philippine, Foidart, Jean-Michel, Arnal, Jean-François, Lenfant, Françoise, Cornil, Charlotte |
| المساهمون: | GIGA Neurosciences-Neuroendocrinology - ULiège |
| المصدر: | Journal of Neuroendocrinology, 35 (10), e13341 (2023-10) |
| بيانات النشر: | John Wiley and Sons Inc |
| سنة النشر: | 2023 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | aromatase, estetrol, estrogen receptor alpha, neuroestrogens, sexual behavior, Estradiol, Estrogens, Receptors, Estrogen, Animals, Female, Male, Mice, Estradiol/metabolism, Motivation, Estrogen Receptor alpha/genetics, Animal, Endocrinology, Diabetes and Metabolism, Endocrine and Autonomic Systems, Cellular and Molecular Neuroscience, Social & behavioral sciences, psychology, Neurosciences & behavior, Sciences sociales & comportementales, psychologie, Neurosciences & comportement |
| الوصف: | peer reviewed ; The activation of male sexual behavior depends on brain estrogen synthesis. Estrogens act through nuclear and membrane receptors producing effects within hours/days or seconds/minutes, respectively. In mice, estrogen receptor alpha (ERα) is the main estrogen receptor (ER) controlling the activation of male sexual behavior. Although neuroestrogens rapidly modulate mouse sexual behavior, it is not known whether these effects involve membrane ERα (mERα). This study combines two complementary approaches to address this question. C451A-ERα mice carry an ERα that cannot signal at the membrane, while estetrol (E4) is a natural estrogen acting as an agonist on nuclear ERα but as an antagonist on membrane ERα. In wild-type males, E4 decreased the number of mounts and intromissions after 10 min. In C451A-ERα males, E4 also altered sexual performance but after 30 min. E4 did not affect time spent near the female in both wild-type and C451A-ERα mice. However, regardless of genotype, the aromatase inhibitor 1,4,6-Androstatriene-3,17-dione (ATD) decreased both sexual performance and the time spent near the female after 10 and 30 min, confirming the key role of aromatization in the rapid control of sexual behavior and motivation. In conclusion, the shift in timing at which the effect of E4 is observed in mice lacking mERα suggests a role for mERα in the regulation of rapid effects of neuroestrogens on sexual performance, thus providing the first demonstration that E4 acts as an antagonist of a mER in the brain. The persisting effect of ATD on behavior in C451A-ERα mice also suggests the implication of another ER. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0953-8194 1365-2826 |
| العلاقة: | urn:issn:0953-8194; urn:issn:1365-2826; https://orbi.uliege.be/handle/2268/311548Test; info:hdl:2268/311548; scopus-id:2-s2.0-85173550304; info:pmid:37806316 |
| DOI: | 10.1111/jne.13341 |
| الإتاحة: | https://doi.org/10.1111/jne.13341Test https://orbi.uliege.be/handle/2268/311548Test |
| حقوق: | restricted access ; http://purl.org/coar/access_right/c_16ecTest ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.CFB96521 |
| قاعدة البيانات: | BASE |
| تدمد: | 09538194 13652826 |
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| DOI: | 10.1111/jne.13341 |