دورية أكاديمية
Fusion transcriptome profiling defines the monoclonal origin of multifocal epithelioid haemangioma of bone
| العنوان: | Fusion transcriptome profiling defines the monoclonal origin of multifocal epithelioid haemangioma of bone |
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| المؤلفون: | Errani C., De Benedictis I., Righi A., Valenti B., Del Savio E., Baldazzi D., Benini S., Sbaraglia M., Vega Jimenez B., Vanel D., Donati D. M., Dei Tos A. P., Maestro R. |
| المساهمون: | Errani, C., De Benedictis, I., Righi, A., Valenti, B., Del Savio, E., Baldazzi, D., Benini, S., Sbaraglia, M., Vega Jimenez, B., Vanel, D., Donati, D. M., Dei Tos, A. P., Maestro, R. |
| سنة النشر: | 2023 |
| المجموعة: | Università degli Studi di Udine: CINECA IRIS |
| مصطلحات موضوعية: | FOS, FOSB, RNA-sequencing, clonal analysi, epithelioid haemangioma of bone, fusion transcript |
| الوصف: | AimsEpithelioid haemangioma (EH) of bone remains a highly controversial entity. Indeed, the WHO classifies EHs of soft tissues as benign tumours, whereas bone EHs are considered intermediate-locally aggressive tumours due to common multifocal presentation and local destructive growth. To gain insights into the clinical behaviour and biology of EH of bone we retrospectively analysed 42 patients treated in a single institution from 1978 to 2021. Methods and resultsMultifocal presentation was detected in 17 of 42 patients (40%) primarily as synchronous lesions. Patients were treated with curettage (57%), resection (29%) or biopsy, followed by radiotherapy or embolisation (14%). Follow-up (minimum 24 months) was available for 38 patients, with only five local recurrences (13%) and no death of disease. To clarify whether the synchronous bone lesions in multifocal EH represent multicentric disease or clonal dissemination, four cases were profiled by RNA-sequencing. Separate lesions from the same patient, which showed a similar transcriptional profile, expressed the same fusion transcript (involving FOS or FOSB) with identical gene breakpoints. ConclusionsThese results indicate that, in EH of bone, multifocal lesions are clonally related and therefore represent the spread of a same neoplastic clone rather than simultaneous independent tumours. This finding is in apparent contradiction with the benign clinical course of the disease, and suggests that tumour dissemination in bone EH probably reflects a phenomenon of passive spreading, with tumour cells colonising distal sites while maintaining their benign biological nature. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:001037222500001; volume:83; issue:5; firstpage:743; lastpage:755; numberofpages:13; journal:HISTOPATHOLOGY; https://hdl.handle.net/11390/1269788Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85166434382 |
| DOI: | 10.1111/his.15016 |
| الإتاحة: | https://doi.org/10.1111/his.15016Test https://hdl.handle.net/11390/1269788Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CFB5DEB6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/his.15016 |
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