دورية أكاديمية
Synthesis and biodistribution of Tc-99m-carbonyltechnetium-labeled fatty acids
| العنوان: | Synthesis and biodistribution of Tc-99m-carbonyltechnetium-labeled fatty acids |
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| المؤلفون: | Chu, TW, Zhang, Y, Liu, XQ, Wang, Y, Hu, SW, Wang, XY |
| المساهمون: | Chu, TW (reprint author), Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China., Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China. |
| المصدر: | EI ; PubMed ; SCI |
| بيانات النشر: | 应用辐射与同位素 |
| سنة النشر: | 2004 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | fatty acid, myocardial metabolism imaging, carbonyl technetium, Tween-80, COMPLEXES, TC-99M, TECHNETIUM, CHEMISTRY, CRYSTAL, LIGAND |
| الوصف: | In order to image myocardial metabolism, Tc-99m(CO)(3)(+) complexes containing fatty acids were evaluated. At first, 11-(1-inudazolyl)-undecanoic acid (IUA) and 11-(2-(4-bromo-phenylazo)-1-imidazolyl)-undecanoic acid (BPIUA) were synthesized and the corresponding carbonyltechnetium-labeled complexes were prepared. However, unfortunately similar to those of other technetium-labeled fatty acid analogs, the biodistribution studies of Tc-99m(CO)(3)-IUA and Tc-99m(CO)(3)-BPIUA in mice demonstrated poor heart-to-blood ratios, thus these complexes cannot be used as heart-imaging reagents. In addition, Tween-80 can improve the biodistribution of the complexes for myocardial imaging. (C) 2004 Elsevier Ltd. All rights reserved. ; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000221315600009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Test ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging ; SCI(E) ; EI ; PubMed ; 21 ; ARTICLE ; 6 ; 845-850 ; 60 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0969-8043 |
| العلاقة: | APPLIED RADIATION AND ISOTOPES.2004,60,(6),845-850.; 676846; http://hdl.handle.net/20.500.11897/150262Test; WOS:000221315600009 |
| DOI: | 10.1016/j.apradiso.2004.02.006 |
| الإتاحة: | https://doi.org/20.500.11897/150262Test https://doi.org/10.1016/j.apradiso.2004.02.006Test https://hdl.handle.net/20.500.11897/150262Test |
| رقم الانضمام: | edsbas.CF8C4CEC |
| قاعدة البيانات: | BASE |
| تدمد: | 09698043 |
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| DOI: | 10.1016/j.apradiso.2004.02.006 |