دورية أكاديمية
LAG-3 Contribution to T Cell Downmodulation during Acute Respiratory Viral Infections
| العنوان: | LAG-3 Contribution to T Cell Downmodulation during Acute Respiratory Viral Infections |
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| المؤلفون: | Rodriguez Guilarte, Linmar Eri Jose, Ramirez Pozo, Mario Andres, Andrade Parra, Catalina Andrea, Kalergis Parra Alexis Mikes |
| بيانات النشر: | MDPI |
| سنة النشر: | 2024 |
| المجموعة: | Pontificia Universidad Católica de Chile: Repositorio UC |
| مصطلحات موضوعية: | LAG-3, Ligand, T cell dysfunction, Viral infections, Medicina y salud, 03 Good Health and Well-being, 03 Salud y bienestar |
| الوقت: | 610 |
| الوصف: | LAG-3 is a type I transmembrane protein expressed on immune cells, such as activated T cells, and binds to MHC class II with high affinity. LAG-3 is an inhibitory receptor, and its multiple biological activities on T cell activation and effector functions play a regulatory role in the immune response. Immunotherapies directed at immune checkpoints, including LAG-3, have become a promising strategy for controlling malignant tumors and chronic viral diseases. Several studies have suggested an association between the expression of LAG-3 with an inadequate immune response during respiratory viral infections and the susceptibility to reinfections, which might be a consequence of the inhibition of T cell effector functions. However, important information relative to therapeutic potential during acute viral lower respiratory tract infections and the mechanism of action of the LAG-3 checkpoint remains to be characterized. In this article, we discuss the contribution of LAG-3 to the impairment of T cells during viral respiratory infections. Understanding the host immune response to respiratory infections is crucial for developing effective vaccines and therapies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 15 páginas; application/pdf |
| اللغة: | English |
| تدمد: | 1999-4915 |
| العلاقة: | https://doi.org/10.3390/v15010147Test; https://repositorio.uc.cl/handle/11534/80992Test; WOS:000926169300001 |
| DOI: | 10.3390/v15010147 |
| الإتاحة: | https://doi.org/10.3390/v15010147Test https://repositorio.uc.cl/handle/11534/80992Test |
| حقوق: | acceso abierto ; Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) ; https://creativecommons.org/licenses/by-nc/4.0/deed.enTest |
| رقم الانضمام: | edsbas.CF87A91D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19994915 |
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| DOI: | 10.3390/v15010147 |