التفاصيل البيبلوغرافية
| العنوان: |
Targeting a neoantigen derived from a common TP53 mutation |
| المؤلفون: |
Hsiue, Emily Han-Chung, Wright, Katharine M., Douglass, Jacqueline, Hwang, Michael S., Mog, Brian J., Pearlman, Alexander H., Paul, Suman, DiNapoli, Sarah R., Konig, Maximilian F., Wang, Qing, Schaefer, Annika, Miller, Michelle S., Skora, Andrew D., Azurmendi, P. Aitana, Murphy, Michael B., Liu, Qiang, Watson, Evangeline, Li, Yana, Pardoll, Drew M., Bettegowda, Chetan, Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Gabelli, Sandra B., Zhou, Shibin |
| المساهمون: |
National Institutes of Health, Howard Hughes Medical Institute, National Cancer Institute, Commonwealth Fund, Lustgarten Foundation, Virginia and D.K. Ludwig Fund for Cancer Research, Mark Foundation For Cancer Research, Bloomberg Philanthropies, The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Burroughs Wellcome Fund, Society for Immunotherapy of Cancer |
| المصدر: |
Science ; volume 371, issue 6533 ; ISSN 0036-8075 1095-9203 |
| بيانات النشر: |
American Association for the Advancement of Science (AAAS) |
| سنة النشر: |
2021 |
| الوصف: |
Turning a tumor suppressor into a target Tumor-suppressor genes such as TP53 (tumor protein P53) play key roles in the pathogenesis of cancer but, unfortunately, they are difficult to target because they do not create an overactive protein that can be inhibited with a drug. Hsiue et al. discovered a way to target a cancer-associated mutant form of the p53 protein using the body's own immune system (see the Perspective by Weidanz). The authors identified a distinct fragment of this mutant protein, characterized the structural basis for its presentation to T cells, and designed a bispecific antibody to stimulate T cell killing of p53-mutant cancer cells. Science , this issue p. eabc8697 ; see also p. 996 |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1126/science.abc8697 |
| الإتاحة: |
https://doi.org/10.1126/science.abc8697Test |
| رقم الانضمام: |
edsbas.CF76C271 |
| قاعدة البيانات: |
BASE |
