دورية أكاديمية
S1 File -
| العنوان: | S1 File - |
|---|---|
| المؤلفون: | Margaret Toluwalayo Arowolo, Oluwatosin Qawiyy Orababa, Morufat Oluwatosin Olaitan, Bisola Victoria Osibeluwo, Utibeima Udo Essiet, Olajumoke Hanah Batholomew, Oluwaseyi Gbotoluwa Ogunrinde, Oluwaseyi Aminat Lagoke, Jeffrey Difiye Soriwei, Olanrewaju David Ishola, Onyinye Maryann Ezeani, Aminat Oyeronke Onishile, Elizabeth Olumodeji |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Microbiology, Genetics, Molecular Biology, Neuroscience, Biotechnology, Evolutionary Biology, Developmental Biology, Cancer, Mental Health, Infectious Diseases, Virology, Computational Biology, |
| الوصف: | Carbapenems are effective drugs against bacterial pathogens and resistance to them is considered a great public health threat, especially in notorious nosocomial pathogens like Acinetobacter baumannii and Pseudomonas aeruginosa . In this study, we aimed to determine the prevalence of carbapenem resistance in A . baumannii and P . aeruginosa infections in Sub-Saharan Africa. Databases (PubMed, Scopus, Web of Science, and African Journal Online) were systematically searched following the Preferred Reporting Items for Systematic review and meta-analysis protocols (PRISMA-P) 2020 statements for articles reporting carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-resistant Pseudomonas aeruginosa (CRPA) prevalence between 2012 and 2022. Pooled prevalence was determined with the random effect model and funnel plots were used to determine heterogeneity in R. A total of 47 articles were scanned for eligibility, among which 25 (14 for carbapenem-resistant A . baumannii and 11 for carbapenem-resistant P . aeruginosa ) were included in the study after fulfilling the eligibility criteria. The pooled prevalence of CRPA in the present study was estimated at 8% (95% CI; 0.02–0.17; I 2 = 98%; P <0.01). There was high heterogeneity (Q = 591.71, I 2 = 98.9%; P<0.0001). In addition, this study’s pooled prevalence of CRAB was estimated at 20% (95% CI; 0.04–0.43; I 2 = 99%; P <0.01). There was high heterogeneity (Q = 1452.57, I 2 = 99%; P<0.0001). Also, a funnel plot analysis of the studies showed high degree of heterogeneity. The carbapenemase genes commonly isolated from A . baumannii in this study include bla OXA23, bla OXA48 , bla GES. , bla NDM, bla VIM , bla OXA24 , bla OXA58 , bla OXA51 , bla SIM-1 , bla OXA40 , bla OXA66 , bla OXA69 , bla OXA91 , with bla OXA23 and bla VIM being the most common. On the other hand, bla NDM, bla VIM , bla IMP , bla OXA48 , bla OXA51 , bla SIM-1 , bla OXA181 , bla KPC , bla OXA23 , bla OXA50 were the commonly isolated carbapenemase genes in P . aeruginosa , among ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/S1_File_-/24651145Test |
| DOI: | 10.1371/journal.pone.0287762.s003 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0287762.s003Test https://figshare.com/articles/journal_contribution/S1_File_-/24651145Test |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.CF4BD540 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0287762.s003 |
|---|