دورية أكاديمية
Combined assessment of stress cardiovascular magnetic resonance and angiography to predict the effect of revascularization in chronic coronary syndrome patients
| العنوان: | Combined assessment of stress cardiovascular magnetic resonance and angiography to predict the effect of revascularization in chronic coronary syndrome patients |
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| المؤلفون: | Gavara-Doñate, Josep, Pérez, Nerea, Marcos-Garces, Victor, Monmeneu, José V., Lopez-Lereu, Maria P., Rios-Navarro, César, De Dios, Elena, Bonanad, Clara, Canoves, Joaquim, Moratal, David, Palau, Patricia, Miñana, Gema, Nunez, Julio, Chorro, Francisco Javier, Bodi, Vicente |
| المساهمون: | Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials, Generalitat Valenciana, Instituto de Salud Carlos III, Agencia Estatal de Investigación, European Regional Development Fund, Sociedad Española de Cardiología, Ministerio de Economía y Competitividad |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2022 |
| المجموعة: | Universitat Politécnica de Valencia: RiuNet / Politechnical University of Valencia |
| مصطلحات موضوعية: | Cardiovascular magnetic resonance, Ischaemic heart disease, Ischaemic burden, Prognosis, All-cause mortality, Revascularization, TECNOLOGIA ELECTRONICA |
| الوصف: | [EN] Aims The role of revascularization in chronic coronary syndrome (CCS) and the value of ischaemia vs. anatomy to guide decision-making are in constant debate. We explored the potential of a combined assessment of ischaemic burden by vasodilator stress cardiovascular magnetic resonance (CMR) and presence of multivessel disease by angiography to predict the effect of revascularization on all-cause mortality in CCS. Methods and results The study group comprised 1066 CCS patients submitted to vasodilator stress CMR pre-cardiac catheterization (mean age 66 +/- 11 years, 69% male). Stress CMR-derived ischaemic burden (extensive if >5 ischaemic segments) and presence of multivessel disease in angiography (two- or three-vessel or left main stem disease) were computed. The influence of revascularization on all-cause mortality was explored and adjusted hazard ratios (HRs) with the corresponding 95% confidence intervals were obtained. During a median 7.51-year follow-up, 557 (52%) CMR-related revascularizations and 308 (29%) deaths were documented. Revascularization exerted a neutral effect on all-cause mortality in the whole study group [HR 0.94 (0.74-1.19), P = 0.6], in patients without multivessel disease [n = 598, 56%, HR 1.12 (0.77-1.62), P = 0.6], and in those with multivessel disease without extensive ischaemic burden [n = 181, 17%, HR 1.66 (0.91-3.04), P = 0.1]. However, compared to non-revascularized patients, revascularization significantly reduced all-cause mortality in patients with simultaneous multivessel disease and extensive ischaemic burden (n = 287, 27%): 3.77 vs. 7.37 deaths per 100 person-years, HR 0.60 (0.40-0.90), P = 0.01. Conclusions In patients with CCS submitted to catheterization, evidence of simultaneous extensive CMR-related ischaemic burden and multivessel disease identifies the subset in whom revascularization can reduce all-cause mortality. ; This work was supported by the Instituto de Salud Carlos III and co-funded by Fondo Europeo de Desarrollo Regional (FEDER) (PI20/00637 and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2047-4873 |
| العلاقة: | European Journal of Preventive Cardiology; info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00637/ES/RESOLUCION DE LA OBSTRUCCION MICROVASCULAR TRAS UN INFARTO DE MIOCARDIO: EVALUACION DE LAS CONSECUENCIAS ESTRUCTURALES Y CLINICAS Y BUSQUEDA DE NUEVAS OPCIONES TERAPEUTICAS./; info:eu-repo/grantAgreement/GVA//AEST%2F2019%2F037/; info:eu-repo/grantAgreement/MINECO//CB16%2F11%2F00486/ES/ENFERMEDADES CARDIOVASCULARES/; info:eu-repo/grantAgreement/GVA//AEST%2F2020%2F029//Aplicación de técnicas de deep learning (aprendizaje profundo) para un análisis automático de imágenes de Resonancia/; info:eu-repo/grantAgreement/Sociedad Española de Cardiología//SEC%2FFECINV-CLI 21%2F024/; info:eu-repo/grantAgreement/AEI//FJC2020-043981-I/; https://doi.org/10.1093/eurjpc/zwab170Test; urn:issn:2047-4873; http://hdl.handle.net/10251/199841Test |
| DOI: | 10.1093/eurjpc/zwab170 |
| الإتاحة: | https://doi.org/10.1093/eurjpc/zwab170Test http://hdl.handle.net/10251/199841Test |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CF0B615F |
| قاعدة البيانات: | BASE |
| تدمد: | 20474873 |
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| DOI: | 10.1093/eurjpc/zwab170 |