دورية أكاديمية
Divergent Associations of Slow-Wave Sleep versus Rapid Eye Movement Sleep with Plasma Amyloid-Beta
| العنوان: | Divergent Associations of Slow-Wave Sleep versus Rapid Eye Movement Sleep with Plasma Amyloid-Beta |
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| المؤلفون: | Rosenblum, Yevgenia, Pereira, Mariana, Stange, Oliver, Weber, Frederik D, Bovy, Leonore, Tzioridou, Sofia, Lancini, Elisa, Neville, David A, Klein, Nadja, de Wolff, Timo, Stritzke, Mandy, Kersten, Iris, Uhr, Manfred, Claassen, Jurgen A H R, Steiger, Axel, Verbeek, Marcel M, Dresler, Martin |
| المصدر: | Rosenblum , Y , Pereira , M , Stange , O , Weber , F D , Bovy , L , Tzioridou , S , Lancini , E , Neville , D A , Klein , N , de Wolff , T , Stritzke , M , Kersten , I , Uhr , M , Claassen , J A H R , Steiger , A , Verbeek , M M & Dresler , M 2024 , ' Divergent Associations of Slow-Wave Sleep versus Rapid Eye Movement Sleep with Plasma Amyloid-Beta ' , Annals of Neurology . https://doi.org/10.1002/ana.26935Test |
| سنة النشر: | 2024 |
| المجموعة: | KNAW: Research Explorer (Koninklijke Nederlandse Akademie van Wetenschappen / Royal Netherlands Academy of Arts and Sciences) |
| الوصف: | OBJECTIVE: Recent evidence shows that during slow-wave sleep (SWS), the brain is cleared from potentially toxic metabolites, such as the amyloid-beta protein. Poor sleep or elevated cortisol levels can worsen amyloid-beta clearance, potentially leading to the formation of amyloid plaques, a neuropathological hallmark of Alzheimer disease. Here, we explored how nocturnal neural and endocrine activity affects amyloid-beta fluctuations in the peripheral blood. METHODS: We acquired simultaneous polysomnography and all-night blood sampling in 60 healthy volunteers aged 20-68 years. Nocturnal plasma concentrations of amyloid-beta-40, amyloid-beta-42, cortisol, and growth hormone were assessed every 20 minutes. Amyloid-beta fluctuations were modeled with sleep stages, (non)oscillatory power, and hormones as predictors while controlling for age and participant-specific random effects. RESULTS: Amyloid-beta-40 and amyloid-beta-42 levels correlated positively with growth hormone concentrations, SWS proportion, and slow-wave (0.3-4Hz) oscillatory and high-band (30-48Hz) nonoscillatory power, but negatively with cortisol concentrations and rapid eye movement sleep (REM) proportion measured 40-100 minutes previously (all t values > |3|, p values < 0.003). Older participants showed higher amyloid-beta-40 levels. INTERPRETATION: Slow-wave oscillations are associated with higher plasma amyloid-beta levels, whereas REM sleep is related to decreased amyloid-beta plasma levels, possibly representing changes in central amyloid-beta production or clearance. Strong associations between cortisol, growth hormone, and amyloid-beta presumably reflect the sleep-regulating role of the corresponding releasing hormones. A positive association between age and amyloid-beta-40 may indicate that peripheral clearance becomes less efficient with age. ANN NEUROL 2024. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://pure.knaw.nl/portal/en/publications/21091731-106e-425b-b6e2-481bbc85898cTest |
| DOI: | 10.1002/ana.26935 |
| الإتاحة: | https://doi.org/10.1002/ana.26935Test https://doi.org/20.500.11755/21091731-106e-425b-b6e2-481bbc85898cTest https://pure.knaw.nl/portal/en/publications/21091731-106e-425b-b6e2-481bbc85898cTest https://hdl.handle.net/20.500.11755/21091731-106e-425b-b6e2-481bbc85898cTest https://pure.knaw.nl/ws/files/1382679765/Rosenblum2024.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CED4DA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ana.26935 |
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