دورية أكاديمية
Capture Hi-C identifies putative target genes at 33 breast cancer risk loci
| العنوان: | Capture Hi-C identifies putative target genes at 33 breast cancer risk loci |
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| المؤلفون: | Baxter, J. S., Leavy, Olivia C., Dryden, N. H., Maguire, S., Johnson, N., Fedele, V., Simigdala, N., Martin, L.-A., Andrews, S., Wingett, S. W., Assiotis, I., Fenwick, K., Chauhan, R., Rust, A. G., Orr, N., Dudbridge, Frank, Haider, S., Fletcher, O. |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2018 |
| المجموعة: | University of Leicester: Leicester Research Archive (LRA) |
| الوصف: | Genome-wide association studies (GWAS) have identified approximately 100 breast cancer risk loci. Translating these findings into a greater understanding of the mechanisms that influence disease risk requires identification of the genes or non-coding RNAs that mediate these associations. Here, we use Capture Hi-C (CHi-C) to annotate 63 loci; we identify 110 putative target genes at 33 loci. To assess the support for these target genes in other data sources we test for associations between levels of expression and SNP genotype (eQTLs), disease-specific survival (DSS), and compare them with somatically mutated cancer genes. 22 putative target genes are eQTLs, 32 are associated with DSS and 14 are somatically mutated in breast, or other, cancers. Identifying the target genes at GWAS risk loci will lead to a greater understanding of the mechanisms that influence breast cancer risk and prognosis. ; Peer-reviewed ; Publisher Version |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | https://www.ncbi.nlm.nih.gov/pubmed/29531215Test; Nature Communications, 2018, 9:1028; http://www.nature.com/articles/s41467-018-03411-9Test; http://hdl.handle.net/2381/41544Test |
| DOI: | 10.1038/s41467-018-03411-9 |
| الإتاحة: | https://doi.org/10.1038/s41467-018-03411-9Test http://www.nature.com/articles/s41467-018-03411-9Test http://hdl.handle.net/2381/41544Test |
| حقوق: | Copyright © the authors, 2018. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| رقم الانضمام: | edsbas.CECD07FF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-018-03411-9 |