دورية أكاديمية
Disruption to the 5-HT7 Receptor Following Hypoxia-Ischemia in the Immature Rodent Brain
| العنوان: | Disruption to the 5-HT7 Receptor Following Hypoxia-Ischemia in the Immature Rodent Brain |
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| المؤلفون: | Wixey, Julie A, Reinebrant, Hanna E, Chand, Kirat K, Buller, Kathryn M |
| بيانات النشر: | Springer |
| سنة النشر: | 2018 |
| المجموعة: | The University of Queensland: UQ eSpace |
| مصطلحات موضوعية: | Astrocytes, Microglia, Minocycline, Neonate, Neuroinflammation, Serotonin, 1303 Biochemistry, 2804 Cellular and Molecular Neuroscience |
| الوصف: | It has become increasingly evident the serotonergic (5-hydroxytryptamine, 5-HT) system is an important central neuronal network disrupted following neonatal hypoxic-ischemic (HI) insults. Serotonin acts via a variety of receptor subtypes that are differentially associated with behavioural and cognitive mechanisms. The 5-HT7 receptor is purported to play a key role in epilepsy, anxiety, learning and memory and neuropsychiatric disorders. Furthermore, the 5-HT7 receptor is highly localized in brain regions damaged following neonatal HI insults. Utilising our well-established neonatal HI model in the postnatal day 3 (P3) rat pup we demonstrated a significant decrease in levels of the 5-HT7 protein in the frontal cortex, thalamus and brainstem one week after insult. We also observed a relative decrease in both the cytosolic and membrane fractions of 5-HT7. The 5-HT7 receptor was detected on neurons throughout the cortex and thalamus, and 5-HT cell bodies in the brainstem. However we found no evidence of 5-HT7 co-localisation on microglia or astrocytes. Moreover, minocycline treatment did not significantly prevent the HI-induced reductions in 5-HT7. In conclusion, neonatal HI injury caused significant disruption to 5-HT7 receptors in the forebrain and brainstem. Yet the use of minocycline to inhibit activated microglia, did not prevent the HI-induced changes in 5-HT7 expression. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1573-6903 0364-3190 |
| العلاقة: | orcid:0000-0002-9716-8170; orcid:0000-0003-4061-4923; orcid:0000-0001-7739-2098 |
| الإتاحة: | https://doi.org/10.1007/s11064-018-2473-3Test https://espace.library.uq.edu.au/view/UQ:717028Test |
| رقم الانضمام: | edsbas.CEBCE401 |
| قاعدة البيانات: | BASE |
| تدمد: | 15736903 03643190 |
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