دورية أكاديمية
Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2
| العنوان: | Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2 |
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| المؤلفون: | Saunders, Nell, Planas, Delphine, Bolland, William, Rodriguez, Christophe, Fourati, Slim, Buchrieser, Julian, Planchais, Cyril, Prot, Matthieu, Staropoli, Isabelle, Guivel-Benhassine, Florence, Porrot, Françoise, Veyer, David, Péré, Hélène, Robillard, Nicolas, Saliba, Madelina, Baidaliuk, Artem, Seve, Aymeric, Hocqueloux, Laurent, Prazuck, Thierry, Rey, Felix, Mouquet, Hugo, Simon-Lorière, Etienne, Bruel, Timothée, Pawlotsky, Jean-Michel, Schwartz, Olivier |
| المساهمون: | Virus et Immunité - Virus and immunity (CNRS-UMR3569), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Vaccine Research Institute Créteil, France (VRI), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Immunologie humorale - Humoral Immunology, Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Génomique évolutive des virus à ARN - Evolutionary genomics of RNA viruses, Institut Pasteur Paris (IP), Hôpital Européen Georges Pompidou APHP (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Génomique fonctionnelle des tumeurs solides = Functional Genomics of Solid Tumors CRC (FunGeST), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Centre Hospitalier Régional d'Orléans (CHRO), Virologie Structurale - Structural Virology, Work in OS lab is funded by Institut Pasteur, Fondation pour la Recherche Médicale (FRM), Urgence COVID-19 Fundraising Campaign of Institut Pasteur, ANRS, the Vaccine Research Institute (ANR-10-LABX-77), Labex IBEID (ANR-10-LABX-62-IBEID), ANR/FRM Flash Covid PROTEO-SARS-CoV-2 and IDISCOVR. Work in UPBI is funded by grant ANR-10-INSB-04-01 and Région Ile-de-France program DIM1-Health. NS is supported by the French Ministry of Higher Education, Research and Innovation. DP is supported by the Vaccine Research Institute. HM lab is funded by the Institut Pasteur, the Milieu Intérieur Program (ANR-10-LABX-69-01), the INSERM, REACTing, EU (RECOVER) and Fondation de France (#00106077) grants. ESL lab is funded by Institut Pasteur and the French Government's Investissement d'Avenir programme, Laboratoire d'Excellence “Integrative Biology of Emerging Infectious Diseases” (grant n°ANR-10-LABX-62-IBEID)., ANR-10-LABX-0077,VRI,Initiative for the creation of a Vaccine Research Institute(2010), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010) |
| المصدر: | ISSN: 2352-3964 ; EBioMedicine ; https://pasteur.hal.science/pasteur-03654246Test ; EBioMedicine, 2022, 77, pp.103934. ⟨10.1016/j.ebiom.2022.103934⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | AY.4.2, Delta, Fusogenicity, Neutralization, SARS-CoV-2, Vaccines, MESH: Antibodies, Monoclonal, Humanized, Viral, MESH: COVID-19, MESH: Humans, MESH: SARS-CoV-2, MESH: Spike Glycoprotein, Coronavirus, MESH: Viral Envelope Proteins, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology |
| الوصف: | International audience ; Background: SARS-CoV-2 lineages are continuously evolving. As of December 2021, the AY.4.2 Delta sub-lineage represented 20 % of sequenced strains in the UK and had been detected in dozens of countries. It has since then been supplanted by Omicron. The AY.4.2 spike displays three additional mutations (T95I, Y145H and A222V) in the N-terminal domain when compared to the original Delta variant (B.1.617.2) and remains poorly characterized.Methods: We compared the Delta and the AY.4.2 spikes, by assessing their binding to antibodies and ACE2 and their fusogenicity. We studied the sensitivity of an authentic AY.4.2 viral isolate to neutralizing antibodies.Findings: The AY.4.2 spike exhibited similar binding to all the antibodies and sera tested, and similar fusogenicity and binding to ACE2 than the ancestral Delta spike. The AY.4.2 virus was slightly less sensitive than Delta to neutralization by a panel of monoclonal antibodies; noticeably, the anti-RBD Imdevimab showed incomplete neutralization. Sensitivity of AY.4.2 to sera from vaccinated individuals was reduced by 1.3 to 3-fold, when compared to Delta.Interpretation: Our results suggest that mutations in the NTD remotely impair the efficacy of anti-RBD antibodies. The spread of AY.4.2 was not due to major changes in spike fusogenicity or ACE2 binding, but more likely to a partially reduced neutralization sensitivity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35290827; pasteur-03654246; https://pasteur.hal.science/pasteur-03654246Test; https://pasteur.hal.science/pasteur-03654246/documentTest; https://pasteur.hal.science/pasteur-03654246/file/1-s2.0-S2352396422001189-main.pdfTest; PUBMED: 35290827; PUBMEDCENTRAL: PMC8917961 |
| DOI: | 10.1016/j.ebiom.2022.103934 |
| الإتاحة: | https://doi.org/10.1016/j.ebiom.2022.103934Test https://pasteur.hal.science/pasteur-03654246Test https://pasteur.hal.science/pasteur-03654246/documentTest https://pasteur.hal.science/pasteur-03654246/file/1-s2.0-S2352396422001189-main.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-ndTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.CE936CD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ebiom.2022.103934 |
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