دورية أكاديمية
Systematic review of preoperative prognostic biomarkers in perihilar cholangiocarcinoma
| العنوان: | Systematic review of preoperative prognostic biomarkers in perihilar cholangiocarcinoma |
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| المؤلفون: | Pawaskar, Rishaan, Huang, Kevin Zhang, Pham, Helen, Nagrial, Adnan, Wong, Mark, O’Neill, Siobhan, Pleass, Henry, Yuen, Lawrence, Lam, Vincent W. T., Richardson, Arthur, Pang, Tony, Nahm, Christopher B. |
| المصدر: | Pawaskar , R , Huang , K Z , Pham , H , Nagrial , A , Wong , M , O’Neill , S , Pleass , H , Yuen , L , Lam , V W T , Richardson , A , Pang , T & Nahm , C B 2024 , ' Systematic review of preoperative prognostic biomarkers in perihilar cholangiocarcinoma ' , Cancers , vol. 16 , no. 4 , 698 , pp. 1-24 . https://doi.org/10.3390/cancers16040698Test |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | biomarkers, disease-free survival, overall survival, perihilar cholangiocarcinoma, prognosis |
| الوصف: | Perihilar cholangiocarcinoma (pCCA) is an uncommon malignancy with generally poor prognosis. Surgery is the primary curative treatment; however, the perioperative mortality and morbidity rates are high, with a low 5-year survival rate. Use of preoperative prognostic biomarkers to predict survival outcomes after surgery for pCCA are not well-established currently. This systematic review aimed to identify and summarise preoperative biomarkers associated with survival in pCCA, thereby potentially improving treatment decision-making. The Embase, Medline, and Cochrane databases were searched, and a systematic review was performed using the PRISMA guidelines. English-language studies examining the association between serum and/or tissue-derived biomarkers in pCCA and overall and/or disease-free survival were included. Our systematic review identified 64 biomarkers across 48 relevant studies. Raised serum CA19-9, bilirubin, CEA, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and tumour MMP9, and low serum albumin were most associated with poorer survival; however, the cutoff values used widely varied. Several promising molecular markers with prognostic significance were also identified, including tumour HMGA2, MUC5AC/6, IDH1, PIWIL2, and DNA index. In conclusion, several biomarkers have been identified in serum and tumour specimens that prognosticate overall and disease-free survival after pCCA resection. These, however, require external validation in large cohort studies and/or in preoperatively obtained specimens, especially tissue biopsy, to recommend their use. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.3390/cancers16040698 |
| الإتاحة: | https://doi.org/10.3390/cancers16040698Test https://researchers.mq.edu.au/en/publications/37bbd5de-00ea-4eed-96c8-69062f53c19aTest https://research-management.mq.edu.au/ws/files/325385088/Publisher_version_open_access_.pdfTest http://www.scopus.com/inward/record.url?scp=85185977894&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CE2DFDE9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers16040698 |
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