دورية أكاديمية
BTN2A1, an immune checkpoint targeting Vγ9Vδ2 T cell cytotoxicity against malignant cells
| العنوان: | BTN2A1, an immune checkpoint targeting Vγ9Vδ2 T cell cytotoxicity against malignant cells |
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| المؤلفون: | Cano, Carla, Pasero, Christine, de Gassart, Aude, Kerneur, Clement, Gabriac, Mélanie, Fullana, Marie, Granarolo, Emilie, Hoet, René, Scotet, Emmanuel, Rafia, Chirine, Herrmann, Thomas, Imbert, Caroline, Gorvel, Laurent, Vey, Norbert, Briantais, Antoine, Le Floch, Anne Charlotte, Olive, Daniel |
| المساهمون: | ImCheck Therapeutics Marseille, Immunobiology of Human αβ and γδ T Cells and Immunotherapeutic Applications (CRCINA-ÉQUIPE 1), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ), Julius-Maximilians-Universität Würzburg (JMU), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes (IPC), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Paoli-Calmettes (IPC), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC) |
| المصدر: | ISSN: 2211-1247. |
| بيانات النشر: | HAL CCSD Elsevier Inc |
| سنة النشر: | 2021 |
| المجموعة: | Université de Nantes: HAL-UNIV-NANTES |
| مصطلحات موضوعية: | BTN2A1, BTN3A, Vγ9Vδ2 T cells, butyrophilins, cancer, immunotherapy, monoclonal antibodies, [SDV.CAN]Life Sciences [q-bio]/Cancer |
| الوصف: | International audience ; The anti-tumor response of Vγ9Vδ2 T cells requires the sensing of accumulated phosphoantigens (pAgs) bound intracellularly to butyrophilin 3A1 (BTN3A1). In this study, we show that butyrophilin 2A1 (BTN2A1) is required for BTN3A-mediated Vγ9Vδ2 T cell cytotoxicity against cancer cells, and that expression of the BTN2A1/BTN3A1 complex is sufficient to trigger Vγ9Vδ2 TCR activation. Also, BTN2A1 interacts with all isoforms of BTN3A (BTN3A1, BTN3A2, BTN3A3), which appears to be a rate-limiting factor to BTN2A1 export to the plasma membrane. BTN2A1/BTN3A1 interaction is enhanced by pAgs and, strikingly, B30.2 domains of both proteins are required for pAg responsiveness. BTN2A1 expression in cancer cells correlates with bisphosphonate-induced Vγ9Vδ2 T cell cytotoxicity. Vγ9Vδ2 T cell killing of cancer cells is modulated by anti-BTN2A1 monoclonal antibodies (mAbs), whose action relies on the inhibition of BTN2A1 binding to the Vγ9Vδ2TCR. This demonstrates the potential of BTN2A1 as a therapeutic target and adds to the emerging butyrophilin-family cooperation pathway in γδ T cell activation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34260935; inserm-03547155; https://inserm.hal.science/inserm-03547155Test; https://inserm.hal.science/inserm-03547155/documentTest; https://inserm.hal.science/inserm-03547155/file/PIIS2211124721007579.pdfTest; PUBMED: 34260935 |
| DOI: | 10.1016/j.celrep.2021.109359 |
| الإتاحة: | https://doi.org/10.1016/j.celrep.2021.109359Test https://inserm.hal.science/inserm-03547155Test https://inserm.hal.science/inserm-03547155/documentTest https://inserm.hal.science/inserm-03547155/file/PIIS2211124721007579.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.CE0C24B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.celrep.2021.109359 |
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