دورية أكاديمية
Evolution of Drug Interactions With Antiretroviral Medication in People With HIV.
| العنوان: | Evolution of Drug Interactions With Antiretroviral Medication in People With HIV. |
|---|---|
| المؤلفون: | El Moussaoui, Majdouline, Lambert, Iseult, MAES, Nathalie, SAUVAGE, Anne-Sophie, FRIPPIAT, Frédéric, MEURIS, Christelle, UURLINGS, Françoise, LECOMTE, Marianne, LEONARD, Philippe, Fombellida, Karine, VAIRA, Dolorès, Vercheval, Christelle, Moutschen, Michel, Darcis, Gilles |
| المصدر: | Open Forum Infectious Diseases, 7 (11), ofaa416 (2020) |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2020 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | HIV, antiretroviral therapy, drug interactions, Human health sciences, Immunology & infectious disease, Sciences de la santé humaine, Immunologie & maladie infectieuse |
| الوصف: | peer reviewed ; BACKGROUND: Polypharmacy and drug interactions are important issues for HIV-infected individuals. The number and nature of those interactions are continuously evolving with the use of new antiretroviral drugs and the aging of HIV-infected individuals. We aimed to analyze this evolution over time. METHODS: This retrospective cohort study was conducted in the University Hospital of Liège (Belgium). Treatments of HIV-infected outpatients attending Liège University Hospital were collected and analyzed in 2012 and 2016. The University of Liverpool HIV drug interactions database was used to determine drug interactions. RESULTS: We included 1038 patients in 2016, of whom 78% had 1 comedication. Polypharmacy was seen in 20% of the cohort. Four percent of the patients presented red flag interactions, and 38% had orange flag interactions. Nonantiretroviral (non-ARV) therapeutic classes involved in drug interactions were mostly cardiovascular and central nervous system drugs. They were followed by hormone drugs and dietary supplements for orange flag interactions. Two factors significantly contributed to both red and orange flag interactions: the number of non-ARV comedications and protease inhibitor-based ARV regimens. The proportion of patients with red or orange flag interactions remained stable from 2012 to 2016. CONCLUSIONS: This study highlights the persistence of an alarming number of contraindicated drug interactions and a high prevalence of potential drug interactions over time. Identification, prevention, and management of drug interactions remain a key priority in HIV care. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2328-8957 |
| العلاقة: | urn:issn:2328-8957; https://orbi.uliege.be/handle/2268/254815Test; info:hdl:2268/254815; scopus-id:2-s2.0-85096768338; info:pmid:33204748 |
| DOI: | 10.1093/ofid/ofaa416 |
| الإتاحة: | https://doi.org/10.1093/ofid/ofaa416Test https://orbi.uliege.be/handle/2268/254815Test |
| حقوق: | restricted access ; http://purl.org/coar/access_right/c_16ecTest ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.CDA5FBDD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23288957 |
|---|---|
| DOI: | 10.1093/ofid/ofaa416 |