دورية أكاديمية
Clinical impact of NOTCH1 and/or FBXW7 mutations, FLASH deletion, and TCR status in pediatric T-cell lymphoblastic lymphoma.
| العنوان: | Clinical impact of NOTCH1 and/or FBXW7 mutations, FLASH deletion, and TCR status in pediatric T-cell lymphoblastic lymphoma. |
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| المؤلفون: | Callens, Celine, Baleydier, Frederic, Lengline, Etienne, Ben Abdelali, Raouf, Petit, Arnaud, Villarese, Patrick, Cieslak, Agata, Minard-Colin, Veronique, Rullier, Anne, Moreau, Anne, Baruchel, André, Schmitt, Claudine, Asnafi, Vahid, Bertrand, Yves, Macintyre, Elizabeth |
| المساهمون: | Cytokines, hématopoïèse et réponse immune (CHRI), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard Lyon -Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'Oncologie Médicale Centre hospitalier Lyon Sud - HCL, Centre Hospitalier Lyon Sud CHU - HCL (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), CIC - Biotherapie - GHU Ouest APHP (CIC-BT 502), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Necker - Enfants Malades AP-HP, CHU Trousseau APHP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratory of molecular mechanisms of hematologic disorders and therapeutic implications (ERL 8254 - Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Immunology, Duke University Medical Center, Laboratoire d'anatomie pathologique, CHU Bordeaux-Groupe hospitalier Pellegrin, Laboratoire de mathématiques et applications UMR 6086 (LMA Poitiers ), Université de Poitiers = University of Poitiers (UP)-Centre National de la Recherche Scientifique (CNRS), Hôpital Robert Debré Paris, Hôpital Robert Debré, Service d'Immunopathologie Hôpital Saint-Louis, Paris, Université Paris Diderot - Paris 7 (UPD7)-Hopital Saint-Louis AP-HP (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Hématologie Pédiatrique CHRU Nancy, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service hématologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Necker - Enfants Malades AP-HP |
| المصدر: | ISSN: 0732-183X. |
| بيانات النشر: | HAL CCSD American Society of Clinical Oncology |
| سنة النشر: | 2012 |
| المجموعة: | Université de Poitiers: Publications de nos chercheurs.ses (HAL) |
| مصطلحات موضوعية: | MESH: Adolescent, MESH: Apoptosis Regulatory Proteins, MESH: Male, MESH: Mutation, MESH: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, MESH: Prognosis, MESH: Receptor, Notch1, MESH: Receptors, Antigen, T-Cell, MESH: Sequence Deletion, MESH: Ubiquitin-Protein Ligases, MESH: Calcium-Binding Proteins, MESH: Cell Cycle Proteins, MESH: Child, Preschool, MESH: F-Box Proteins, MESH: Female, MESH: Humans, MESH: Infant, [SDV.CAN]Life Sciences [q-bio]/Cancer |
| الوصف: | International audience ; PURPOSE: Pediatric T-cell lymphoblastic lymphomas (T-LBL) are commonly treated on T-cell acute lymphoblastic leukemia (T-ALL) -derived protocols. Therapeutic stratification based on response to the prephase treatment and on minimal residual disease assessment is well established in T-ALL but is not easy to extrapolate to T-LBL. The identification of molecular prognostic markers at diagnosis in T-LBL could provide an alternative for early therapeutic stratification. Our study determines the frequency and prognostic value of NOTCH1/FBXW7 mutations (N/F(mut)), FLASH deletion at chromosome 6q, and TCR rearrangements in a prospective cohort of pediatric T-LBL. PATIENTS AND METHODS: Pathologic samples were obtained at diagnosis for 54 patients treated according to the EuroLB02 protocol in France. N/F(mut) were identified by direct sequencing and allelic dosage was used to detect FLASH and TCRγ deletions, which were interpreted in conjunction with TCRγ, TCRβ, and TCRδ rearrangements. RESULTS: N/F(mut) were found in 55% of T-LBL patients, in whom they were associated with improved event-free survival (P < .01) and overall survival (P < .01). FLASH monoallelic deletions were observed in 18% of patients; they were predominantly N/F wild-type (six of nine) and tended to be of inferior prognosis (P = .09). Absence of biallelic TCRγ deletion (ABD) was seen in 7%, all of which were N/F(mut) and identified a poor prognosis group (P = .02). On multivariate analysis of N/F(mut), TCRγ ABD, and FLASH deletion, only N/F(mut) was an independent factor for good prognosis. CONCLUSION: Mutational status of NOTCH1/FBXW7 represents a promising marker for early therapeutic stratification in pediatric T-LBL. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/22547598; hal-01010748; https://hal.science/hal-01010748Test; PUBMED: 22547598 |
| DOI: | 10.1200/JCO.2011.39.7661 |
| الإتاحة: | https://doi.org/10.1200/JCO.2011.39.7661Test https://hal.science/hal-01010748Test |
| رقم الانضمام: | edsbas.CD7087A4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1200/JCO.2011.39.7661 |
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