دورية أكاديمية
Oral administration of quercetin and fisetin potentiates photocarcinogenesis in UVR-exposed hairless mice
| العنوان: | Oral administration of quercetin and fisetin potentiates photocarcinogenesis in UVR-exposed hairless mice |
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| المؤلفون: | Pihl, Celina, Granborg, Jonatan Riber, Pinto, Fernanda Endringer, Bjerring, Peter, Andersen, Flemming, Janfelt, Christian, Haedersdal, Merete, Lerche, Catharina Margrethe |
| المصدر: | Pihl , C , Granborg , J R , Pinto , F E , Bjerring , P , Andersen , F , Janfelt , C , Haedersdal , M & Lerche , C M 2024 , ' Oral administration of quercetin and fisetin potentiates photocarcinogenesis in UVR-exposed hairless mice ' , Phytomedicine plus , vol. 4 , no. 2 , 100547 . https://doi.org/10.1016/j.phyplu.2024.100547Test |
| سنة النشر: | 2024 |
| المجموعة: | Aalborg University (AAU): Publications / Aalborg Universitet: Publikationer |
| مصطلحات موضوعية: | Hairless mice, Oral delivery, Photoprotection, Phytochemicals, Skin cancer, Ultraviolet radiation |
| الوصف: | Background: Phytochemicals have demonstrated great potential as photoprotectants. Apple-derived compounds such as quercetin, fisetin, and rutin are reported to provide topical photoprotection, but oral delivery has not been explored. Purpose: To determine the photoprotective effects of oral administration of quercetin, fisetin, and rutin, and their accumulation in skin assessed through mass spectrometry imaging. Study design: Groups of 25 hairless mice (n = 125 mice) received in the daily feed 100 mg/kg quercetin, fisetin, or rutin, 600 mg/kg nicotinamide in water as a positive control, or no supplementation as the UV control. The animals were exposed to ultraviolet radiation (UVR) equivalent to 3.5 standard erythema doses thrice weekly. Method: Mass spectroemetry imaging was used to assess local skin accumulation. Results: Oral administration of quercetin and fisetin reduced the time to tumour onset (Quercetin: second and third tumour [p < 0.045]; fisetin: third tumour [p < 0.021]), with no observed effect for rutin. Nicotinamide delayed the onset of all three recorded tumours (p < 0.0082). Results were supported by accelerated tumour growth following quercetin treatment (p < 0.0069), whereas nicotinamide reduced tumour growth (p < 0.00015). Skin accumulation of the compounds could not be demonstrated, suggesting other mechanisms must be explored to explain these effects on UVR-induced carcinogenesis. Conclusion: Oral administration of quercetin and fisetin to hairless mice increased UVR-induced tumour development. These results indicate a need for caution when selecting candidates for photoprotectants. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://vbn.aau.dk/da/publications/1a8636e8-34be-4e22-8a38-db3f765c1ad2Test |
| DOI: | 10.1016/j.phyplu.2024.100547 |
| الإتاحة: | https://doi.org/10.1016/j.phyplu.2024.100547Test https://vbn.aau.dk/da/publications/1a8636e8-34be-4e22-8a38-db3f765c1ad2Test https://vbn.aau.dk/ws/files/705592837/Pihl_et_al._2024_._Oral_administration_of_quercetin_and_fisetin_potentiates_photocarcinogenesis_in_UVR-exposed_hairless_mice.pdfTest http://www.scopus.com/inward/record.url?scp=85188704822&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CD67B117 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.phyplu.2024.100547 |
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