التفاصيل البيبلوغرافية
| العنوان: |
Mesothelioma in situ of the peritoneum: report of three cases and review of the literature |
| المؤلفون: |
Symes, Emily, Tjota, Melissa, Cody, Brittany, Kindler, Hedy, Mitchell, Owen, Witmer, Hunter, Turaga, Kiran, Mueller, Jeffrey, Krausz, Thomas, Husain, Aliya N., Li, Huihua |
| المصدر: |
Histopathology ; volume 84, issue 3, page 492-506 ; ISSN 0309-0167 1365-2559 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2023 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Aim Diagnosis of mesothelioma in situ (MIS) is historically controversial and, until recently, specific features defining the entity have not been well characterized. Most reported cases of MIS occurred in the pleura; peritoneal MIS is very rare. This study investigates the morphologic features and results of ancillary testing in peritoneal MIS. Methods We present three patients with peritoneal MIS, as defined by a single layer of mesothelial cells with loss of nuclear BRCA‐1‐associated protein‐1 (BAP1) immunostaining and without evidence of invasive tumour by microscopic evaluation, imaging, or direct examination of the peritoneum. Histology and immunostains were reviewed by three expert thoracic pathologists with multidisciplinary input. Next‐generation sequencing (NGS) was performed in all three cases. A literature review was conducted to characterize this rare precursor lesion. Results BAP1 was lost in all three lesions, while methylthioadenosine phosphorylase (MTAP) was retained in two (not performed in the third). NGS revealed BAP1 pathogenic alterations in all three cases as well as mutations of SMO , ERCC3 , TET2 , and U2AF1 . Progression to invasive mesothelioma occurred in one patient at 13 months postdiagnosis (case 1). One patient was diagnosed at age 24 and was later found to harbour a BAP1 germline mutation (case 3). Conclusion This work describes the histologic features and clinicopathologic characteristics of peritoneal MIS in three cases, highlights BAP1 somatic and germline mutations in peritoneal MIS, and strengthens the importance of ancillary studies (including immunohistochemical and molecular studies) in the diagnosis of MIS. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/his.15092 |
| الإتاحة: |
https://doi.org/10.1111/his.15092Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.CD23C8BD |
| قاعدة البيانات: |
BASE |
