دورية أكاديمية
Evaluation clinique de la fonction du thymus. ; Clinical evaluation of thymic function
| العنوان: | Evaluation clinique de la fonction du thymus. ; Clinical evaluation of thymic function |
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| المؤلفون: | Castermans, Emilie, Morrhaye, Gabriel, Marchand, S., Martens, Henri, Moutschen, Michel, Baron, Frédéric, Beguin, Yves, Geenen, Vincent |
| المصدر: | Revue Médicale de Liège, 62 (11), 675-8 (2007) |
| بيانات النشر: | Université de Liège. Revue Médicale de Liège |
| سنة النشر: | 2007 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | DNA, Circular, Gene Rearrangement, T-Lymphocyte/immunology, Humans, Polymerase Chain Reaction, Positron-Emission Tomography, Receptors, Antigen, T-Cell/metabolism, T-Lymphocytes/immunology, Thymus Gland/physiology/radionuclide imaging, Human health sciences, Hematology, Sciences de la santé humaine, Hématologie |
| الوصف: | peer reviewed ; The essential role of the thymus is to install an extremely diverse repertoire of T lymphocytes that are self-tolerant and competent against non-self, as well as to generate self-antigen specific regulatory T cells (Treg) able to inactivate in periphery self-reactive T cells having escaped the thymic censorship. Although indirect, techniques of medical imaging and phenotyping of peripheral T cells may help in the investigation of thymic function. Nowadays however, thymopoiesis is better evaluated through quantification by PCR of T-cell receptor excision circles (TREC) generated by intrathymic random recombination of the gene segments coding for the variable parts of the T-cell receptor for antigen (TCR). The TREC methodology is very valuable in the circumstances not associated with intense proliferation or apoptosis of peripheral T lymphocytes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | French |
| تدمد: | 0370-629X 2566-1566 |
| العلاقة: | urn:issn:0370-629X; urn:issn:2566-1566; https://orbi.uliege.be/handle/2268/6981Test; info:hdl:2268/6981; https://orbi.uliege.be/bitstream/2268/6981/1/233.pdfTest; scopus-id:2-s2.0-39549084519; info:pmid:18217644 |
| الإتاحة: | https://orbi.uliege.be/handle/2268/6981Test https://orbi.uliege.be/bitstream/2268/6981/1/233.pdfTest |
| حقوق: | open access ; http://purl.org/coar/access_right/c_abf2Test ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CCDBBE03 |
| قاعدة البيانات: | BASE |
| تدمد: | 0370629X 25661566 |
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