دورية أكاديمية
Intermittently scanned continuous glucose monitoring in adults with type 1 diabetes: A subgroup analysis from the FLASH-UK study.
| العنوان: | Intermittently scanned continuous glucose monitoring in adults with type 1 diabetes: A subgroup analysis from the FLASH-UK study. |
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| المؤلفون: | Leelarathna, Lalantha, Sutton, Christopher J, Evans, Mark L, Neupane, Sankalpa, Rayman, Gerry, Lumley, Sarah, Cranston, Iain, Narendran, Parth, Krishan, Ashma, Taxiarchi, Vicky P, Barnard-Kelly, Katharine, Elliott, Rachel A, Burns, Matthew, Camm, Maisie, Thabit, Hood, Wilmot, Emma G, FLASH-UK Trial Study Group |
| بيانات النشر: | Wiley Department of Medicine //dx.doi.org/10.1111/dme.15249 Diabet Med |
| سنة النشر: | 2023 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | FLASH-UK Trial Study Group |
| الوصف: | BACKGROUND: The FLASH-UK trial showed lower HbA1c with intermittently-scanned continuous glucose monitoring (isCGM), as compared with self-monitoring of blood glucose (SMBG), in adults with type 1 diabetes and HbA1c ≥58 mmol/mol. (≥ 7.5%). Here we present results from the pre-specified subgroup analysis for the 24-week HbA1c (primary outcome) and selected sensor-based secondary outcomes. METHODS: This was a multicentre, parallel-design, randomised controlled trial. The difference in treatment effect between subgroups (baseline HbA1c (≤75 vs >75 mmol/mol (≤9.0 vs > 9.0%), treatment modality (pump vs injections), prior participation in structured education, age, educational level, impaired awareness of hypoglycaemia, deprivation index quintile sex, ethnic group, and Patient Health Questionnaire-9 (PHQ-9) detected depression category) were evaluated. RESULTS: One hundred fifty-six participants [females 44%, mean (SD) baseline HbA1c 71 (9) mmol/mol 8.6(0.8%), age 44 (15)] were randomly assigned, in a 1:1 ratio to isCGM (n=78) or SMBG (n=78). The mean (SD) baseline HbA1c (%) was 8.7 (0.9) in the isCGM group and 8.5 (0.8) in the SMBG group, lowering to 7.9 (0.8) vs 8.3 (0.9) respectively at 24 weeks (adjusted mean difference -0.5, 95% confidence interval[CI] -0.7 to -0.3; p<0.001]. For HbA1c, there was no impact of treatment modality, prior participation in structured education, deprivation index quintile, sex or baseline depression category. The between-group difference in HbA1c was larger for younger people [a reduction of 2.7 (95%CI 0.3 to 5.0; p=0.028) mmol/mol for every additional 15 years of age]. Those with HbA1c 76-97 mmol/mol (>9.0-11.0%) had a marginally non-significant higher reduction in HbA1c of 8.4 mmol/mol (3.3 to 13.5) compared to 3.1 (0.3 to 6.0) in those with HbA1c 58-75mmol/mol (p=0.08). For "Time in range" (% 3.9 to 10 mmol/l), the difference was larger for those with at least a bachelor's degree. For "Time below range" (% <3.9 mmol/l), the difference was larger for those using ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/358614Test; https://doi.org/10.17863/CAM.102153Test |
| DOI: | 10.17863/CAM.102153 |
| الإتاحة: | https://doi.org/10.17863/CAM.102153Test https://www.repository.cam.ac.uk/handle/1810/358614Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.CC96971C |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.102153 |
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