دورية أكاديمية
Stimulation of the Tibial nerve Repetitively to Improve Incontinence in Parkinson’s Electronically (STRIPE trial):a randomised control trial of tibial nerve stimulation for bladder symptoms in Parkinson’s disease using a self-contained wearable device
| العنوان: | Stimulation of the Tibial nerve Repetitively to Improve Incontinence in Parkinson’s Electronically (STRIPE trial):a randomised control trial of tibial nerve stimulation for bladder symptoms in Parkinson’s disease using a self-contained wearable device |
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| المؤلفون: | Smith, Matthew, Tenison, Emma, Drake, Marcus J., Ben-Shlomo, Yoav, Henderson, Emily J. |
| المصدر: | Smith , M , Tenison , E , Drake , M J , Ben-Shlomo , Y & Henderson , E J 2022 , ' Stimulation of the Tibial nerve Repetitively to Improve Incontinence in Parkinson’s Electronically (STRIPE trial) : a randomised control trial of tibial nerve stimulation for bladder symptoms in Parkinson’s disease using a self-contained wearable device ' , Trials , vol. 23 , no. 1 , 912 . https://doi.org/10.1186/s13063-022-06827-3Test |
| سنة النشر: | 2022 |
| المجموعة: | University of Bristol: Bristol Reserach |
| مصطلحات موضوعية: | /dk/atira/pure/core/keywords/ageing_and_movement_research_group, name=Ageing and Movement Research Group, Bladder symptoms, Neuromodulation, Parkinson’s disease, Randomised control trial, Tibial nerve stimulation |
| الوصف: | Background: Bladder symptoms are common in Parkinson’s disease (PD), affecting half of all individuals. These have significant impact on quality of life as well as implications for morbidity, contributing to falls and hospital admission. The treatment of bladder symptoms can be complicated by the tendency to side-effects in people with PD including cognitive impairment and gait instability with anti-muscarinics. The development of new, better treatments is therefore warranted. Tibial nerve stimulation is a form of neuromodulation demonstrated to improve overactive bladder symptoms in non-neurogenic cohorts. Previously requiring hospital attendance, we aim to explore the use of this intervention using a simple device that can be used by patients at home. Methods: STRIPE is a phase II randomised control trial of tibial nerve stimulation delivered by the Geko™ device, a small, self-adhesive neuromuscular stimulation device currently used for thromboembolism prophylaxis post-surgery. Active tibial nerve stimulation will be compared to sham stimulation, with participants blinded to treatment allocation and undertaking outcome assessment whilst still blinded. Participants will be asked to self-administer stimulation at home twice per week, for 30 min per session, over the course of 3 months. Primary outcome measure will be the International Consultation on Incontinence Overactive Bladder Questionnaire (OAB) at week 12. Secondary outcomes will include pre- and post-intervention bladder diary (frequency, urgency episodes, nocturia), patient perception of global change, bowel function and bladder-related quality of life. Participants will be recruited from the Proactive Integrated Management and Empowerment (PRIME) cross-sectional trial in which participants have been screened for bladder symptoms and invited to take part, as well as clinician referral from around the region. Discussion: This trial will involve a randomised control trial of a novel and easy to use method of delivering tibial nerve stimulation for PD in ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research-information.bris.ac.uk/en/publications/9ed52e8f-4287-4abe-ae11-b47d046e715cTest |
| DOI: | 10.1186/s13063-022-06827-3 |
| الإتاحة: | https://doi.org/10.1186/s13063-022-06827-3Test https://hdl.handle.net/1983/9ed52e8f-4287-4abe-ae11-b47d046e715cTest https://research-information.bris.ac.uk/en/publications/9ed52e8f-4287-4abe-ae11-b47d046e715cTest http://www.scopus.com/inward/record.url?scp=85140835428&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CC8802E4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13063-022-06827-3 |
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