دورية أكاديمية
The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity
| العنوان: | The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity |
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| المؤلفون: | Laoui, Damya, Keirsse, Jiri, Morias, Yannick, Van Overmeire, Eva, Geeraerts, Xenia, Elkrim, Yvon, Kiss, Mate, Bolli, Evangelia, Lahmar, Qods, Sichien, Dorine, Serneels, Jens, Scott, Charlotte, Boon, Louis, De Baetselier, Patrick, Mazzone, Massimiliano, Guilliams, Martin, Van Ginderachter, Jo A. |
| المصدر: | NATURE COMMUNICATIONS ; ISSN: 2041-1723 |
| سنة النشر: | 2016 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Biology and Life Sciences, Medicine and Health Sciences, CYTOKINE GM-CSF, T-CELLS, INTRATUMORAL DELIVERY, CANCER-IMMUNOTHERAPY, STEADY-STATE, IN-VIVO, RESPONSES, SUBSETS, MACROPHAGES, DIFFERENTIATION |
| الوصف: | Various steady state and inflamed tissues have been shown to contain a heterogeneous DC population consisting of developmentally distinct subsets, including cDC1s, cDC2s and monocyte-derived DCs, displaying differential functional specializations. The identification of functionally distinct tumour-associated DC (TADC) subpopulations could prove essential for the understanding of basic TADC biology and for envisaging targeted immunotherapies. We demonstrate that multiple mouse tumours as well as human tumours harbour ontogenically discrete TADC subsets. Monocyte-derived TADCs are prominent in tumour antigen uptake, but lack strong T-cell stimulatory capacity due to NO-mediated immunosuppression. Pre-cDC-derived TADCs have lymph node migratory potential, whereby cDC1s efficiently activate CD8(+) Tcells and cDC2s induce Th17 cells. Mice vaccinated with cDC2s displayed a reduced tumour growth accompanied by a reprogramming of pro-tumoural TAMs and a reduction of MDSCs, while cDC1 vaccination strongly induces anti-tumour CTLs. Our data might prove important for therapeutic interventions targeted at specific TADC subsets or their precursors. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://biblio.ugent.be/publication/8507540Test; http://hdl.handle.net/1854/LU-8507540Test; http://dx.doi.org/10.1038/ncomms13720Test; https://biblio.ugent.be/publication/8507540/file/8507542Test |
| DOI: | 10.1038/ncomms13720 |
| الإتاحة: | https://doi.org/10.1038/ncomms13720Test https://biblio.ugent.be/publication/8507540Test http://hdl.handle.net/1854/LU-8507540Test https://biblio.ugent.be/publication/8507540/file/8507542Test |
| حقوق: | Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CC34B0A2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ncomms13720 |
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