دورية أكاديمية
Is House Dust Mite Specific Sublingual_x000D_ Immunotherapy Successful in Termination of Inhaled_x000D_ Corticosteroid Treatment in Children with Asthma ; Ev Tozu Akarına Spesifik Dilaltı İmmunoterapi Astımlı Çocuklarda İnhale Kortikosteroid Tedavisini Sonlandırmada Ne Kadar Başarılı?
| العنوان: | Is House Dust Mite Specific Sublingual_x000D_ Immunotherapy Successful in Termination of Inhaled_x000D_ Corticosteroid Treatment in Children with Asthma ; Ev Tozu Akarına Spesifik Dilaltı İmmunoterapi Astımlı Çocuklarda İnhale Kortikosteroid Tedavisini Sonlandırmada Ne Kadar Başarılı? |
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| المساهمون: | Elif EROLU, Elif KARAKOÇ AYDINER, Safa BARIŞ, Nerin BAHÇECİLER, Cevdet ÖZDEMİR |
| سنة النشر: | 2018 |
| الوصف: | Objective: House dust mite (HDM)- specific sublingual immunotherapy (SLIT) has long-term effects contrary to pharmacotherapyin children with asthma. We aimed to study the long-term effects ofSLIT on inhaled corticosteroid usage.Material and Method: Fifty-four asthmatic children who receivedHDM -specific SLIT for at least 3 years and were followed up fora minimum 5 years after cessation of SLIT in addition to pharmacotherapy and 23 patients who received only pharmacotherapyduring the same time period were admitted in the study. SLIT andpharmacotherapy groups were evaluated retrospectively by scanning their medical records in regard to their inhaled corticosteroid(ICS) dose (μg/day), duration (month(s)/year) of ICS, and pulmonary function test (PFT) parameters. Visual analogue scores andsymptom scores recorded for 6 months in their daily record cardsgiven to them were evaluated, and dose (μg/day), and duration ofICS therapy (month(s)/year) were calculated PFTs were performedfor each patient. Based on the diary card records regardingsymptoms, the need for ICS and FEV1%, the patients were grouped as 37 SLIT-responders, 17 SLIT-nonresponders, 15PT-responders, and 8 PT-nonresponders.Results: Reduction in ICS dose was significantly higher for SLIT(407±252 μg)n group in comparison to pharmacotherapy group(224±174 μg) (p=0.009). Duration of ICS usage reduced by 63%(p=0,001) in SLIT-nonresponder group, but in pharmacotherapynonresponder group it decreased by only 11% (p=0,108).Conclusion: SLIT was effective in reducing ICS dose. Duration of ICStreatment did not decrease in the course of time in PT-nonrespondergroup while decreased in SLIT-nonresponder group. ; Amaç: Ev tozu akarı (HDM) spesifik sublingual immünoterapinin_x000D_ (SLIT) astımlı çocuklarda farmakoterapinin (PT) aksine uzun_x000D_ süreli etkileri vardır. SLIT’in inhale kortikosteroid kullanımı üzerine uzun süreli etkilerini incelemeyi amaçladık._x000D_ Gereç ve Yöntem: En az 3 yıl boyunca HDM’ye spesifik SLİT_x000D_ almış ve SLIT tedavisinden sonra en az 5 ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | İstanbul Kanuni Sultan Süleyman Tıp Dergisi; 2148-273X;null; https://hdl.handle.net/11424/253705Test |
| DOI: | 10.5222/iksst.2018.57070 |
| الإتاحة: | https://doi.org/10.5222/iksst.2018.57070Test https://hdl.handle.net/11424/253705Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CC158D71 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5222/iksst.2018.57070 |
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