دورية أكاديمية
Serum tryptophan metabolites are associated with erosive hand osteoarthritis and pain: results from the DIGICOD cohort
| العنوان: | Serum tryptophan metabolites are associated with erosive hand osteoarthritis and pain: results from the DIGICOD cohort |
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| المؤلفون: | Binvignat, M., Emond, P., Mifsud, F., Miao, B., Courties, A., Lefèvre, A., Maheu, E., Crema, M.D., Klatzmann, D., Kloppenburg, M., Richette, P., Butte, A.J., Mariotti-Ferrandiz, E., Berenbaum, F., Sokol, H., Sellam, J. |
| المساهمون: | Sorbonne Université (SU), Université de Tours (UT), Université Paris Cité (UPCité), University of California San Francisco (UC San Francisco), University of California (UC), CHU Saint-Antoine AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut national du sport, de l'expertise et de la performance (INSEP), Universiteit Leiden = Leiden University |
| المصدر: | ISSN: 1063-4584. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | Université François-Rabelais de Tours: HAL |
| مصطلحات موضوعية: | Erosive hand osteoarthritis, Gut microbiome, Hand osteoarthritis, Metabolomic, Pain, Symptoms, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; AbstractObjective: To investigate host and gut-microbiota related Tryptophan metabolism in hand osteoarthritis (HOA).Methods: The baseline serum concentration of 20 Tryptophan metabolites was measured in 416 HOA patients in a cross-sectional analysis of the DIGICOD cohort. Tryptophan metabolites levels, metabolite-ratios and metabolism pathway activation were compared between erosive (N = 141) and non-erosive HOA (N = 275) by multiple logistic regressions adjusted on age, BMI and sex. The association between Tryptophan metabolite levels and HOA symptoms was investigated by a Spearman's rank correlation analysis.Results: Four serum Tryptophan metabolites, eight metabolite ratios and one metabolism pathway were associated with erosive HOA. Erosive HOA was negatively associated with Tryptophan (odds ratio (OR) = 0.41, 95% confidence interval [0.24-0.70]), indole-3-aldehyde (OR = 0.67 [0.51-0.90]) and 3-OH-anthranilic acid (OR = 1.32 [1.13-1.54]) and positively with 5-OH-Tryptophan levels (OR = 1.41 [1.13-1.77]). The pro-inflammatory kynurenine-indoleamine 2,3-dioxygenase pathway was upregulated in erosive HOA (OR = 1.60 [1.11-2.29]). Eleven metabolites were correlated with HOA symptoms and were mostly pain-related. Serotonin and N-acetyl serotonin levels were negatively correlated with number of tender joints. Indole-3-aldehyde level was negatively correlated and 3-OH-anthranilic acid, 3-OH-kynurenine and 5-OH-Tryptophan levels were positively correlated with number of patients-reported painful joints. Quinolinic acid and 3-OH-kynurenine levels correlated positively with AUSCAN pain.Conclusions: Tryptophan metabolites disturbance is associated with erosive HOA and pain and emphasize the role of low-grade inflammation and gut dysbiosis in HOA. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04190253; https://hal.sorbonne-universite.fr/hal-04190253Test; https://hal.sorbonne-universite.fr/hal-04190253/documentTest; https://hal.sorbonne-universite.fr/hal-04190253/file/HAL_2023_TRP_DIGICOD%20%281%29.pdfTest |
| DOI: | 10.1016/j.joca.2023.04.007 |
| الإتاحة: | https://doi.org/10.1016/j.joca.2023.04.007Test https://hal.sorbonne-universite.fr/hal-04190253Test https://hal.sorbonne-universite.fr/hal-04190253/documentTest https://hal.sorbonne-universite.fr/hal-04190253/file/HAL_2023_TRP_DIGICOD%20%281%29.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.CB9F73A2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.joca.2023.04.007 |
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