دورية أكاديمية
HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry
| العنوان: | HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry |
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| المؤلفون: | Paoletti, Audrey, Allouch, Awatef, Caillet, Marina, Saidi, Héla, Subra, Frédéric, Nardacci, Roberta, Wu, Qiuji, Muradova, Zeinaf, Voisin, Laurent, Raza, Syed Qasim, Law, Fredéric, Thoreau, Maxime, Dakhli, Haithem, Delelis, Olivier, Poirier-Beaudouin, Beatrice, Dereuddre-Bosquet, Nathalie, Le Grand, Roger, Lambotte, Olivier, Saez-Cirion, Asier, Pancino, Gianfranco, Ojcius, David M., Solary, Eric, Deutsch, Eric, Piacentini, Mauro, Gougeon, Marie-Lise, Kroemer, Guido, Perfettini, Jean-Luc |
| المساهمون: | Radiothérapie moléculaire (UMR 1030), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Apoptose, cancer et immunité (U848), Immunité Anti-virale, Biothérapie et Vaccins (IABV), Institut Pasteur Paris (IP), Laboratoire de Biologie et de Pharmacologie Appliquée (LBPA), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Istituto Nazionale di Malattie Infettive "Lazzaro Spallanzani" (INMI), Immunologie des Maladies Virales et Autoimmunes (IMVA - U1184), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Infectious Diseases Models for Innovative Therapies (IDMIT), Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), HIV, Inflammation et persistance - HIV, Inflammation and Persistence, University of the South Pacific (USP), Université Paris Diderot - Paris 7 (UPD7), Hématopoïèse normale et pathologique, Département de radiothérapie Gustave Roussy, Institut Gustave Roussy (IGR), Università degli Studi di Roma Tor Vergata Roma = University of Rome Tor Vergata, Agence Nationale de la RechercheFrench National Research Agency (ANR) ANR-10-IBHU-0001, ANR-10-LABX33, ANR-11-IDEX-003-01, Electricite de France, MIUR (FIRB)Ministero dell' Istruzione, dell' Universita e della Ricerca (MIUR), Ministry of Health of Italy "Ricerca Finalizzata", ANR under the program "Investissements d'Avenir''French National Research Agency (ANR) ANR-10-LABX-33, ANR-11-IDEX-0003-01, Fondation Gustave Roussy, AIRCAssociazione Italiana per la Ricerca sul Cancro (AIRC), European Commission "Transpath'' Marie Curie Project, Agence Nationale de Recherche sur le Sida et sur les Hepatites (ANRSH)French National Research Agency (ANR), Higher Education Commission (Pakistan)Higher Education Commission of Pakistan, Laboratory of Excellence LERMIT, Institut National du CancerInstitut National du Cancer (INCA) France INCA 9414, Canceropole Ile-de-FranceRegion Ile-de-France, Institut National du Cancer (INCa)Institut National du Cancer (INCA) France, NATIXIS, Sidaction, French National Agency for Research on AIDS and Viral Hepatitis (ANRSH)French National Research Agency (ANR), Ligue contre le Cancer (equipe labellisee), Agence National de la Recherche (ANR) -Projets blancsFrench National Research Agency (ANR), Institut Universitaire de France, Ministry of Health of Italy "Ricerca Corrente'', LabEx Immuno-Oncology, RHU Torino Lumiere, SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE), SIRIC Cancer Research and Personalized Medicine (CARPEM), MIUR (PRIN 2012)Ministero dell' Istruzione, dell' Universita e della Ricerca (MIUR), We gratefully acknowledge Y. Lecluse and S. Salome-Desnoulez for technical support., ANR-10-IBHU-0001,MMO (IHU-CANCER),Institut de Médecine Personnalisée du Cancer(2010), ANR-11-IDEX-0003,IPS,Idex Paris-Saclay(2011), European Project: 289964,EC:FP7:PEOPLE,FP7-PEOPLE-2011-ITN,TRANSPATH(2011) |
| المصدر: | ISSN: 2211-1247. |
| بيانات النشر: | HAL CCSD Elsevier Inc |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | HIV, CBL, inflammasome, viral entry, P2Y2, NLRP3, [INFO.INFO-DL]Computer Science [cs]/Digital Libraries [cs.DL] |
| الوصف: | International audience ; Purinergic receptors and nucleotide-binding domain leucine-rich repeat containing (NLR) proteins have been shown to control viral infection. Here, we show that the NLR family member NLRP3 and the purinergic receptor P2Y2 constitutively interact and regulate susceptibility to HIV-1 infection. We found that NLRP3 acts as an inhibitory factor of viral entry that represses F-actin remodeling. The binding of the HIV-1 envelope to its host cell receptors (CD4, CXCR4, and/or CCR5) overcomes this restriction by stimulating P2Y2. Once activated, P2Y2 enhances its interaction with NLRP3 and stimulates the recruitment of the E3 ubiquitin ligase CBL to NLRP3, ultimately leading to NLRP3 degradation. NLRP3 degradation is permissive for PYK2 phosphorylation (PYK2Y402*) and subsequent F-actin polymerization, which is required for the entry of HIV-1 into host cells. Taken together, our results uncover a mechanism by which HIV-1 overcomes NLRP3 restriction that appears essential for the accomplishment of the early steps of HIV-1 entry. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31553908; info:eu-repo/grantAgreement/EC/FP7/289964/EU/Transglutaminase in disease: a novel therapeutic target?/TRANSPATH; cea-02316814; https://cea.hal.science/cea-02316814Test; https://cea.hal.science/cea-02316814/documentTest; https://cea.hal.science/cea-02316814/file/1-s2.0-S2211124719302815-main.pdfTest; PUBMED: 31553908 |
| DOI: | 10.1016/j.celrep.2019.02.095 |
| الإتاحة: | https://doi.org/10.1016/j.celrep.2019.02.095Test https://cea.hal.science/cea-02316814Test https://cea.hal.science/cea-02316814/documentTest https://cea.hal.science/cea-02316814/file/1-s2.0-S2211124719302815-main.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-ndTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.CB49096E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.celrep.2019.02.095 |
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