التفاصيل البيبلوغرافية
| العنوان: |
Copyright � The Korean Academy of Medical Sciences ERK-1/-2 and p38 Kinase Oppositely Regulate 15-deoxy- △ 12,14- prostaglandinJ2-Induced PPAR- Activation That Mediates Dedifferentiation But Not Cyclooxygenase-2 Expression in Articular Chondrocytes |
| المؤلفون: |
Eun-kyung Yoon, Won-kil Lee, Sang-gu Hwang, Song-ja Kim |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c3/09/J_Korean_Med_Sci_2007_Dec_20_22(6)_1015-1021.tar.gz |
| سنة النشر: |
2007 |
| المجموعة: |
CiteSeerX |
| مصطلحات موضوعية: |
These authors contributed equally to this work |
| الوصف: |
Peroxisome proliferator-activated receptor gamma (PPAR-) is a ligand-activated transcription factor and plays an important role in growth, differentiation, and inflammation in different tissues. In this study, we investigated the effects of 15d-PGJ2, a high-affinity ligand of PPAR-, on dedifferentiation and on inflammatory responses such as COX-2 expression and PGE2 production in rabbit articular chondrocytes with a focus on ERK-1/-2, p38 kinase, and PPAR- activation. We report here that 15d-PGJ2 induced dedifferentiation and/or COX-2 expression and subsequent PGE2 production. 15d-PGJ2 treatment stimulated activation of ERK-1/-2, p38 kinase, and PPAR-. Inhibition of ERK-1/-2 with PD98059 recovered 15d-PGJ2-induced dedifferentiation and enhanced PPAR- activation, whereas inhibition of p38 kinase with SB203580 potentiated dedifferentiation and partially blocked PPAR- activation. Inhibition of ERK-1/-2 and p38 kinase abolished 15d-PGJ2-induced COX-2 expression and subsequent PGE2 production. Our findings collectively suggest that ERK-1/-2 and p38 kinase oppositely regulate 15d-PGJ2-induced dedifferentiation through a PPAR--dependent mechanism, whereas COX-2 expression and PGE2 |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/zip |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.359.3046Test |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.CB465EB5 |
| قاعدة البيانات: |
BASE |
