دورية أكاديمية
No evidence of increased anti-M3 muscarinic acetylcholine receptor autoantibodies in SSA-positive connective tissue disease patients
| العنوان: | No evidence of increased anti-M3 muscarinic acetylcholine receptor autoantibodies in SSA-positive connective tissue disease patients |
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| المؤلفون: | Korsholm, Trine-Line, Dahl, Marie Louise Næstholt, Hvid, Malene, Mikkelsen, Jakob Hauge, Deleuran, Bent, Hatipoğlu, Elif |
| سنة النشر: | 2023 |
| الوصف: | Anti-muscarinic type 3 receptor autoantibodies (M3R) and anti-SSA antibodies are both related to salivary secretion. The presence of M3R antibodies in Sjögren's syndrome is previously demonstrated; nevertheless, the relationship between the anti-SSA antibodies and M3R fragment antibodies, namely the N terminal, first, second, and third extracellular loops, remains to be elucidated. In this study, we analyzed the antibodies against the M3R epitopes in healthy controls and anti-SSA antibody-positive connective tissue disease patients through ELISA method. Antibodies against the first, second, and third extracellular loop (M3R211–230) were not increased in anti-SSA positive patients compared to healthy controls. Indeed, antibodies against the N terminal (M3R1–33) were found to be high in healthy controls. High levels of M3R1–33 in healthy controls are a novel original finding; further research is needed for the clinical significance. There is no significant difference between SSA-positive patients and healthy controls in terms of autoantibodies against the remainder of the linear M3R fragments. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | 26997a31-c9ab-4a53-8714-9418321726d4; https://avesis.hacettepe.edu.tr/publication/details/26997a31-c9ab-4a53-8714-9418321726d4/oaiTest |
| DOI: | 10.1111/apm.13349 |
| الإتاحة: | https://doi.org/10.1111/apm.13349Test https://avesis.hacettepe.edu.tr/publication/details/26997a31-c9ab-4a53-8714-9418321726d4/oaiTest |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.CAE6AF6E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/apm.13349 |
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