التفاصيل البيبلوغرافية
| العنوان: |
Do's and Don'ts in Primary Aneurysmal Bone Cysts of the Proximal Femur in Children and Adolescents : Retrospective Multicenter EPOS Study of 79 Patients |
| المؤلفون: |
the EPOS Study Group, van Geloven, Thomas P. G., van der Heijden, Lizz, Laitinen, Minna K., Campanacci, Domenico A., Doring, Kevin, Dammerer, Dietmar, Badr, Ismail T., Haara, Mikko, Beltrami, Giovanni, Kraus, Tanja, Scheider, Philipp, Soto-Montoya, Camilo, Umer, Masood, Fiocco, Marta, Coppa, Valentino, de Witte, Pieter B., van de Sande, Michiel A. J. |
| المساهمون: |
University of Helsinki, Department of Surgery, I kirurgian klinikka (Töölö), HUS Musculoskeletal and Plastic Surgery, HUS Children and Adolescents, Children's Hospital, Lastenkirurgian yksikkö |
| بيانات النشر: |
Lippincott Williams & Wilkins |
| سنة النشر: |
2023 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
Abc, Bearing, Benign bone tumor, Hip, Pediatric, Percutaneous treatment, Survival, Weight, 3126 Surgery, anesthesiology, intensive care, radiology, 3123 Gynaecology and paediatrics |
| الوصف: |
Background:Aneurysmal bone cysts (ABC) are rare benign cystic bone tumors, generally diagnosed in children and adolescents. Proximal femoral ABCs may require specific treatment strategies because of an increased pathologic fracture risk. As few reports are published on ABCs, specifically for this localization, consensus regarding optimal treatment is lacking. We present a large retrospective study on the treatment of pediatric proximal femoral ABCs. Methods:All eligible pediatric patients with proximal femoral ABC were included, from 11 tertiary referral centers for musculo-skeletal oncology (2000-2021). Patient demographics, diagnostics, treatments, and complications were evaluated. Index procedures were categorized as percutaneous/open procedures and osteosynthesis alone. Primary outcomes were: time until full weight-bearing and failure-free survival. Failure was defined as open procedure after primary surgery, >3 percutaneous procedures, recurrence, and/or fracture. Risk factors for failure were evaluated. Results:Seventy-nine patients with ABC were included [mean age, 10.2 (+/- SD4.0) y, n=56 male]. The median follow-up was 5.1 years (interquartile ranges=2.5 to 8.8).Index procedure was percutaneous procedure (n=22), open procedure (n=35), or osteosynthesis alone (n=22). The median time until full weight-bearing was 13 weeks [95% confidence interval (CI)=7.9-18.1] for open procedures, 9 weeks (95% CI=1.4-16.6) for percutaneous, and 6 weeks (95% CI=4.3-7.7) for osteosynthesis alone (P=0.1). Failure rates were 41%, 43%, and 36%, respectively. Overall, 2 and 5-year failure-free survival was 69.6% (95% CI=59.2-80.0) and 54.5% (95% CI=41.6-67.4), respectively. Risk factors associated with failure were age younger than 10 years [hazard ratios (HR)=2.9, 95% CI=1.4-5.8], cyst volume >55 cm(3) (HR=1.7, 95% CI=0.8-2.5), and fracture at diagnosis (HR=1.4, 95% CI=0.7-3.3). Conclusions:As both open and percutaneous procedures along with osteosynthesis alone seem viable treatment options in this weight-bearing ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
the EPOS Study Group , van Geloven , T P G , van der Heijden , L , Laitinen , M K , Campanacci , D A , Doring , K , Dammerer , D , Badr , I T , Haara , M , Beltrami , G , Kraus , T , Scheider , P , Soto-Montoya , C , Umer , M , Fiocco , M , Coppa , V , de Witte , P B & van de Sande , M A J 2023 , ' Do's and Don'ts in Primary Aneurysmal Bone Cysts of the Proximal Femur in Children and Adolescents : Retrospective Multicenter EPOS Study of 79 Patients ' , Journal of Pediatric Orthopaedics , vol. 43 , no. 1 , pp. 37-45 . https://doi.org/10.1097/BPO.0000000000002267Test; ORCID: /0000-0002-9975-0121/work/131065514; 7658fe90-2214-4acf-b043-dbb5ebf2e4ba; http://hdl.handle.net/10138/356267Test; 000920190900013 |
| الإتاحة: |
http://hdl.handle.net/10138/356267Test |
| حقوق: |
cc_by ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.CA4DE9E4 |
| قاعدة البيانات: |
BASE |
