دورية أكاديمية
Chemotherapy of vascularised tumours: Role of vessel density and the effect of vascular 'pruning'
| العنوان: | Chemotherapy of vascularised tumours: Role of vessel density and the effect of vascular 'pruning' |
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| المؤلفون: | d'Onofrio, Alberto, Gandolfi, Alberto |
| المساهمون: | Department of Experimental Oncology, European Institute of Oncology Milan (ESMO), Istituto di Analisi dei Sistemi ed Informatica "A. Ruberti" - CNR, Istituto di Analisi dei Sistemi ed Informatica "Antonio Ruberti" Roma (IASI), National Research Council of Italy |
| المصدر: | ISSN: 0022-5193. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2010 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | Tumour, Angiogenesis, Chemotherapy, Pruning, Multistability |
| الوصف: | International audience ; In this work we propose to model chemotherapy taking into account the mutual interaction between tumour growth and the development of tumour vasculature. By adopting a simple model for this interaction, and assuming that the efficacy of a drug can be modulated by the vessel density, we study the constant continuous therapy, the periodic bolus-based therapy, and combined therapy in which a chemoterapic drug is associated with an anti-angiogenic agent. The model allows to represent the vessel-disrupting activity of some standard chemotherapic drugs, and shows, in the case of constant continuous drug administration, the possibility of multiple stable equilibria. The multistability suggests an explanation for some sudden losses of control observed during therapy, and for the beneficial effect of vascular "pruning" exherted by anti-angiogenic agents in combined therapy. Moreover, in case of periodic therapies in which the drug amount administered per unit time is constant ("metronomic" delivery), the model predicts a response, as function of the bolus frequency, significantly influenced by the extent of the anti-angiogenic activity of the chemotherapic drug and by the dependence of the drug efficacy on the vessel density. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-00585792; https://hal.science/hal-00585792Test; https://hal.science/hal-00585792/documentTest; https://hal.science/hal-00585792/file/PEER_stage2_10.1016%252Fj.jtbi.2010.01.023.pdfTest |
| DOI: | 10.1016/j.jtbi.2010.01.023 |
| الإتاحة: | https://doi.org/10.1016/j.jtbi.2010.01.023Test https://hal.science/hal-00585792Test https://hal.science/hal-00585792/documentTest https://hal.science/hal-00585792/file/PEER_stage2_10.1016%252Fj.jtbi.2010.01.023.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.CA429595 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jtbi.2010.01.023 |
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