التفاصيل البيبلوغرافية
| العنوان: |
Tetrodotoxin-Bupivacaine-Epinephrine Combinations for Prolonged Local Anesthesia |
| المؤلفون: |
Charles B. Berde, Umeshkumar Athiraman, Barak Yahalom, David Zurakowski, Gabriel Corfas, Christina Bognet |
| المصدر: |
Marine Drugs; Volume 9; Issue 12; Pages: 2717-2728 |
| بيانات النشر: |
Molecular Diversity Preservation International |
| سنة النشر: |
2011 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
tetrodotoxin, bupivacaine, epinephrine, local anesthesia, sciatic blockade |
| جغرافية الموضوع: |
agris |
| الوصف: |
Currently available local anesthetics have analgesic durations in humans generally less than 12 hours. Prolonged-duration local anesthetics will be useful for postoperative analgesia. Previous studies showed that in rats, combinations of tetrodotoxin (TTX) with bupivacaine had supra-additive effects on sciatic block durations. In those studies, epinephrine combined with TTX prolonged blocks more than 10-fold, while reducing systemic toxicity. TTX, formulated as Tectin, is in phase III clinical trials as an injectable systemic analgesic for chronic cancer pain. Here, we examine dose-duration relationships and sciatic nerve histology following local nerve blocks with combinations of Tectin with bupivacaine 0.25% (2.5 mg/mL) solutions, with or without epinephrine 5 µg/mL (1:200,000) in rats. Percutaneous sciatic blockade was performed in Sprague-Dawley rats, and intensity and duration of sensory blockade was tested blindly with different Tectin-bupivacaine-epinephrine combinations. Between-group comparisons were analyzed using ANOVA and post-hoc Sidak tests. Nerves were examined blindly for signs of injury. Blocks containing bupivacaine 0.25% with Tectin 10 µM and epinephrine 5 µg/mL were prolonged by roughly 3-fold compared to blocks with bupivacaine 0.25% plain (P < 0.001) or bupivacaine 0.25% with epinephrine 5 µg/mL (P < 0.001). Nerve histology was benign for all groups. Combinations of Tectin in bupivacaine 0.25% with epinephrine 5 µg/mL appear promising for prolonged duration of local anesthesia. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://dx.doi.org/10.3390/md9122717Test |
| DOI: |
10.3390/md9122717 |
| الإتاحة: |
https://doi.org/10.3390/md9122717Test |
| حقوق: |
https://creativecommons.org/licenses/by/3.0Test/ |
| رقم الانضمام: |
edsbas.C94917D3 |
| قاعدة البيانات: |
BASE |
