دورية أكاديمية
Beneficial molecular adaptations in BRCA-mutation carriers by combined HIT/HIRT intervention: results from a pilot study
| العنوان: | Beneficial molecular adaptations in BRCA-mutation carriers by combined HIT/HIRT intervention: results from a pilot study |
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| المؤلفون: | Bizjak, Daniel A., Schulz, Sebastian V. W., Schumann, Uwe, Otto, Stephanie, Kirsten, Johannes, Ebner, Florian, Leinert, Elena, Huober, Jens, Janni, Wolfgang, Steinacker, Jürgen Michael |
| بيانات النشر: | Universität Ulm |
| سنة النشر: | 2022 |
| المجموعة: | OPARU (OPen Access Repository of Ulm University) |
| مصطلحات موضوعية: | combination HIT/HIRT program, molecular adaptations, BRCA protein/gene expression, anti-oxidative stress/inflammatory response, BRCA1, DDC 610 / Medicine & health, Breast neoplasms, Genetics, Genes, Biomarkers, Genetic predisposition to disease, Oxidative stress, Brustkrebs, Biomarker, Gen BRCA 1, Oxidativer Stress |
| الوصف: | Based on growing evidence that breast cancer (BRCA) also plays a pivotal role in the regulation of skeletal muscle metabolism and the response to anti-oxidative stress, we examined the influence of regular exercise in human BRCA mutation carriers on their BRCA1 gene/protein expression and inflammatory/oxidative response. Sixteen BRCA-mutation carriers were assigned to an intervention (IG) or control group (CG). IG received a combination of high-intensity interval endurance (HIT) and strength training (HIRT) for six weeks, whereas CG received a low-intensity activity program. Before (T0) and at the end of the intervention (T1), muscle biopsy, physiological performance, blood withdrawal and anthropometry were obtained. Parameters included: Muscle BRCA1 gene/protein expression, inflammatory/oxidative stress, anti-oxidative capacity, peak oxygen capacity (VO2peak) and 1-repetition maximum (1-RM) at six different training machines. VO2peak and 1-RM of IG were increased at T1 compared to T0, whereas CG performance, physiological and molecular parameters remained unchanged. IG showed increased BRCA1 protein concentration as well as anti-oxidative capacity, whereas gene expression was unaltered. IG inflammatory and oxidative damage did not differ between time points. Combined HIT/HIRT increases aerobic and strength performance of BRCA-mutation carriers with up regulated BRCA1 protein expression and improved anti-oxidative status without showing an increased inflammatory response. ; publishedVersion |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://www.mdpi.com/2072-6694/12/6/1526/s1Test; http://dx.doi.org/10.18725/OPARU-44337Test; https://oparu.uni-ulm.de/xmlui/123456789/44413Test; http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-44413-7Test |
| DOI: | 10.18725/OPARU-44337 |
| الإتاحة: | https://doi.org/10.18725/OPARU-44337Test https://oparu.uni-ulm.de/xmlui/123456789/44413Test http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-44413-7Test |
| حقوق: | CC BY 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.C92EAC7C |
| قاعدة البيانات: | BASE |
| DOI: | 10.18725/OPARU-44337 |
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