دورية أكاديمية
T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP
| العنوان: | T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP |
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| المؤلفون: | Perruzza, Lisa, Gargari, Giorgio, Proietti, Michele, Fosso, Bruno, D'Erchia, Anna Maria, Faliti, Caterina Elisa, Rezzonico-Jost, Tanja, Scribano, Daniela, Mauri, Laura, Colombo, Diego, Pellegrini, Giovanni, Moregola, Annalisa, Mooser, Catherine, Pesole, Graziano, Nicoletti, Mauro, Norata, Giuseppe Danilo, Geuking, Markus B, McCoy, Kathy D, Guglielmetti, Simone, Grassi, Fabio |
| المساهمون: | Perruzza, Lisa, Gargari, Giorgio, Proietti, Michele, Fosso, Bruno, D'Erchia, Anna Maria, Faliti, Caterina Elisa, Rezzonico-Jost, Tanja, Scribano, Daniela, Mauri, Laura, Colombo, Diego, Pellegrini, Giovanni, Moregola, Annalisa, Mooser, Catherine, Pesole, Graziano, Nicoletti, Mauro, Norata, Giuseppe Danilo, Geuking, Markus B, Mccoy, Kathy D, Guglielmetti, Simone, Grassi, Fabio |
| سنة النشر: | 2017 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | atp, iga, p2rx7, T follicular helper cell, metabolism, microbiota, adenosine triphosphate, animal, body weight, extracellular space, gastrointestinal microbiome, glucose, immunoglobulin a, intestine, small, mice, inbred C57BL, receptors, purinergic P2X7, t-lymphocytes, Helper-Inducer, Homeostasis |
| الوصف: | The ATP-gated ionotropic P2X7 receptor regulates Tfollicular helper (Tfh) cell abundance in the Peyer's patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of microbiota-derived extracellular ATP via P2X7 promotes the generation of a proficient gut ecosystem for metabolic homeostasis. The results of this study indicate that Tfh cells play a role in host-microbiota mutualism beyond protecting the intestinal mucosa by induction of affinity-matured IgA and suggest that extracellular ATP constitutes an inter-kingdom signaling molecule important for selecting a beneficial microbial community for the host via P2X7-mediated regulation of B cell help. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/28297661; info:eu-repo/semantics/altIdentifier/wos/WOS:000397330000003; volume:18; issue:11; firstpage:2566; lastpage:2575; numberofpages:10; journal:CELL REPORTS; http://hdl.handle.net/11573/1527281Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85015222021 |
| DOI: | 10.1016/j.celrep.2017.02.061 |
| الإتاحة: | https://doi.org/10.1016/j.celrep.2017.02.061Test http://hdl.handle.net/11573/1527281Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C90C57BA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.celrep.2017.02.061 |
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