التفاصيل البيبلوغرافية
| العنوان: |
CXC chemokines and antimicrobial peptides in rhinovirus‐induced experimental asthma exacerbations |
| المؤلفون: |
Rohde, G., Message, S. D., Haas, J. J., Kebadze, T., Parker, H., Laza‐Stanca, V., Khaitov, M. R., Kon, O. M., Stanciu, L. A., Mallia, P., Edwards, M. R., Johnston, S. L. |
| المساهمون: |
European Respiratory Society, Medical Research Council, British Medical Association HC Roscoe, Asthma UK, British Lung Foundation/Severin Wunderman Family Foundation, Wellcome Trust, National Institute for Health Research, NIHR Biomedical Research Centre |
| المصدر: |
Clinical & Experimental Allergy ; volume 44, issue 7, page 930-939 ; ISSN 0954-7894 1365-2222 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2014 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Summary Rationale Rhinoviruses (RVs) are the major triggers of asthma exacerbations. We have shown previously that lower respiratory tract symptoms, airflow obstruction, and neutrophilic airway inflammation were increased in experimental RV‐induced asthma exacerbations. Objectives We hypothesized that neutrophil‐related CXC chemokines and antimicrobial peptides are increased and related to clinical, virologic, and pathologic outcomes in RV‐induced exacerbations of asthma. Methods Protein levels of antimicrobial peptides ( SLPI , HNP 1–3, elafin, and LL ‐37) and neutrophil chemokines ( CXCL 1/ GRO ‐α, CXCL 2/ GRO ‐β, CXCL 5/ ENA ‐78, CXCL 6/ GCP ‐2, CXCL 7/ NAP ‐2, and CXCL 8/ IL ‐8) were determined in bronchoalveolar lavage ( BAL ) fluid of 10 asthmatics and 15 normal controls taken before, at day four during and 6 weeks post‐experimental infection. Results BAL HNP 1–3 and Elafin were higher, CXCL 7/ NAP ‐2 was lower in asthmatics compared with controls at day 4 ( P = 0.035, P = 0.048, and P = 0.025, respectively). BAL HNP 1–3 and CXCL 8/ IL ‐8 were increased during infection ( P = 0.003 and P = 0.011, respectively). There was a trend to increased BAL neutrophils at day 4 compared with baseline ( P = 0.076). BAL HNP 1–3 was positively correlated with BAL neutrophil numbers at day 4. There were no correlations between clinical parameters and HNP 1–3 or IL ‐8 levels. Conclusions We propose that RV infection in asthma leads to increased release of CXCL 8/ IL ‐8, attracting neutrophils into the airways where they release HNP 1–3, which further enhances airway neutrophilia. Strategies to inhibit CXCL 8/ IL ‐8 may be useful in treatment of virus‐induced asthma exacerbations. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/cea.12313 |
| الإتاحة: |
https://doi.org/10.1111/cea.12313Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.C8D7F2B6 |
| قاعدة البيانات: |
BASE |
