دورية أكاديمية
Gene by Environment interaction and metabolic-associated fatty liver disease in Mexican American patients with depression
| العنوان: | Gene by Environment interaction and metabolic-associated fatty liver disease in Mexican American patients with depression |
|---|---|
| المؤلفون: | Sheikh, Khalid, Diego, Vincent P., Laston, Sandra L., Manusov, Eron G., Williams-Blangero, Sarah, Blangero, John |
| المصدر: | Research Colloquium |
| بيانات النشر: | ScholarWorks @ UTRGV |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Mexican American, Gene by Environment, Depression, Metabolic Fatty Liver Disease, Biochemical Phenomena, Metabolism, and Nutrition, Disorders of Environmental Origin, Medical Genetics, Medicine and Health Sciences, Nutritional and Metabolic Diseases |
| الوصف: | Knowledge of genetic and environmental (G x E) interaction effects on metabolic-associated fatty liver disease (MAFLD) is limited. The purpose of this study was to examine the impact of G x E interaction effects on MAFLD in Mexican Americans in the Rio Grande Valley (RGV). The environment examined was depression as measured by the Beck Depression Inventory-II (BDI-II). We examined potential G x E interaction in the phenotypic expression of MAFLD, including hepatic steatosis and hepatic fibrosis, using variance component models and likelihood-based statistical inference. Significant G x E interactions were identified for hepatic fibrosis x BDI-II. These findings provide evidence that genetic factors interact with depression to influence expression of hepatic fibrosis. A better understanding of these genetic interactions are necessary to develop strategies and interventions to reduce the bi-directional relationship of hepatic fibrosis and depression. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://scholarworks.utrgv.edu/colloquium/2022/posters/24Test; https://scholarworks.utrgv.edu/context/colloquium/article/1114/viewcontent/poster_presentationPPTFinal.pdfTest; https://scholarworks.utrgv.edu/context/colloquium/article/1114/filename/0/type/additional/viewcontent/poster_presentationPPTFinal.pdfTest |
| الإتاحة: | https://scholarworks.utrgv.edu/colloquium/2022/posters/24Test https://scholarworks.utrgv.edu/context/colloquium/article/1114/viewcontent/poster_presentationPPTFinal.pdfTest https://scholarworks.utrgv.edu/context/colloquium/article/1114/filename/0/type/additional/viewcontent/poster_presentationPPTFinal.pdfTest |
| رقم الانضمام: | edsbas.C8B9B814 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |