دورية أكاديمية
Aerosol assisted synthesis of a pH responsive curcumin anticancer drug nanocarrier using chitosan and alginate natural polymers
| العنوان: | Aerosol assisted synthesis of a pH responsive curcumin anticancer drug nanocarrier using chitosan and alginate natural polymers |
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| المؤلفون: | Asadi, Sepideh, Madrakian, Tayyebeh, Ahmadi, Mazaher, Aguirre Pastor, Miguel Ángel, Afkhami, Abbas, Uroomiye, Seyed Sepehr, Ghaffari, Fatemeh, Ranjbar, Akram |
| المساهمون: | Universidad de Alicante. Departamento de Química Analítica, Nutrición y Bromatología, Universidad de Alicante. Instituto Universitario de Materiales, Espectroscopía Atómica-Masas y Química Analítica en Condiciones Extremas |
| بيانات النشر: | Springer Nature |
| سنة النشر: | 2023 |
| المجموعة: | RUA - Repositorio Institucional de la Universidad de Alicante |
| مصطلحات موضوعية: | Aerosol assisted synthesis, pH responsive, Curcumin anticancer, Drug nanocarriers, Chitosan, Alginate, Natural polymers |
| الوصف: | In recent years, several nanocarrier synthesis methods have been developed. In cancer therapy, the use of smart nanocarriers is of interest. Smart nanocarriers respond to their environment and can release their cargo in a controlled manner under the action of internal or external stimuli. In this work, we report on the development of an aerosol-assisted method for the synthesis of curcumin-loaded chitosan/alginate-based polymeric nanocarrier (CurNCs). A custom-fabricated multi-nebulizer system was utilized for the synthesis of CurNCs. The developed system comprises three main parts a sprayer, an electric heater tunnel, and a collector. Curcumin and chitosan solutions were sprayed using a pneumatic multinebulizer into the electric heater tunnel to form chitosan-curcumin assemblies. Then, the aerosol was guided into the collector solution containing sodium alginate and tri-poly phosphate aqueous solution for further cross-linkage. The synthesized CurNCs were characterized using TEM, DLS, and FTIR techniques. The TEM size of the nanoparticles was 8.62 ± 2.25 nm. The release experiments revealed that the nanocarrier is sensitive to the environment pH as more curcumin is released at acidic pH values (as is the case for cancerous tissues) compared to physiological pH. The curcumin content of the nanocarrier was 77.27 mg g−1 with a drug loading efficiency of 62%. The in-vitro cytotoxicity of the synthesized nanocarrier was evaluated against the MCF7 breast cancer cell line. The IC50 concentrations for CurNCs and curcumin were obtained as 14.86 and 16.45 mg mL−1, respectively. The results showed that while the empty nanocarrier shows non-significant cytotoxicity, the CurNCs impact the cell culture and cause prolonged cell deaths. Overall, pH-responsive curcumin polymeric nanocarrier was synthesized using a custom fabricated aerosol-based method. The method enabled fast and feasible synthesis of the nanocarrier with high efficiency. ; This work has been supported by grants from the Bu-Ali Sina University Research Council ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | https://doi.org/10.1038/s41598-023-46904-4Test; Scientific Reports. 2023, 13: 19389. https://doi.org/10.1038/s41598-023-46904-4Test; http://hdl.handle.net/10045/138488Test |
| DOI: | 10.1038/s41598-023-46904-4 |
| الإتاحة: | https://doi.org/10.1038/s41598-023-46904-4Test http://hdl.handle.net/10045/138488Test |
| حقوق: | © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0Test/. ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C88D363E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-023-46904-4 |