دورية أكاديمية
Inflammation and Oxidative Stress in Diabetic Kidney Disease: The Targets for SGLT2 Inhibitors and GLP-1 Receptor Agonists
| العنوان: | Inflammation and Oxidative Stress in Diabetic Kidney Disease: The Targets for SGLT2 Inhibitors and GLP-1 Receptor Agonists |
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| المؤلفون: | Agata Winiarska, Monika Knysak, Katarzyna Nabrdalik, Janusz Gumprecht, Tomasz Stompór |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 10822, p 10822 (2021) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | type 2 diabetes, sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor antagonists, diabetic kidney disease, oxidative stress, inflammation, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The incidence of type 2 diabetes (T2D) has been increasing worldwide, and diabetic kidney disease (DKD) remains one of the leading long-term complications of T2D. Several lines of evidence indicate that glucose-lowering agents prevent the onset and progression of DKD in its early stages but are of limited efficacy in later stages of DKD. However, sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor (GLP-1R) antagonists were shown to exert nephroprotective effects in patients with established DKD, i.e., those who had a reduced glomerular filtration rate. These effects cannot be solely attributed to the improved metabolic control of diabetes. In our review, we attempted to discuss the interactions of both groups of agents with inflammation and oxidative stress—the key pathways contributing to organ damage in the course of diabetes. SGLT2i and GLP-1R antagonists attenuate inflammation and oxidative stress in experimental in vitro and in vivo models of DKD in several ways. In addition, we have described experiments showing the same protective mechanisms as found in DKD in non-diabetic kidney injury models as well as in some tissues and organs other than the kidney. The interaction between both drug groups, inflammation and oxidative stress appears to have a universal mechanism of organ protection in diabetes and other diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/22/19/10822Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test; https://doaj.org/article/92e00e02cf5d411da35b9cb0c24ebab7Test |
| DOI: | 10.3390/ijms221910822 |
| الإتاحة: | https://doi.org/10.3390/ijms221910822Test https://doaj.org/article/92e00e02cf5d411da35b9cb0c24ebab7Test |
| رقم الانضمام: | edsbas.C8840C5E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms221910822 |