دورية أكاديمية
Attention-deficit/hyperactivity disorder and lifetime cannabis use:genetic overlap and causality
| العنوان: | Attention-deficit/hyperactivity disorder and lifetime cannabis use:genetic overlap and causality |
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| المؤلفون: | Soler Artigas, María, Sánchez-Mora, Cristina, Rovira, Paula, Richarte, Vanesa, Garcia-Martínez, Iris, Pagerols, Mireia, Demontis, Ditte, Stringer, Sven, Vink, Jacqueline M., Børglum, Anders D., Neale, Benjamin M., Franke, Barbara, Faraone, Stephen V., Casas, Miguel, Ramos-Quiroga, Josep Antoni, Ribasés, Marta |
| المصدر: | Soler Artigas , M , Sánchez-Mora , C , Rovira , P , Richarte , V , Garcia-Martínez , I , Pagerols , M , Demontis , D , Stringer , S , Vink , J M , Børglum , A D , Neale , B M , Franke , B , Faraone , S V , Casas , M , Ramos-Quiroga , J A , Ribasés , M , ADHD Group of the Psychiatric Genomics Consortium, International Cannabis Consortium & International Cannabis Consortium 2020 , ' Attention-deficit/hyperactivity disorder and lifetime cannabis use : genetic overlap and causality ' .... |
| سنة النشر: | 2020 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | CHILDHOOD ADHD, DEFICIT-HYPERACTIVITY DISORDER, GENOME-WIDE ASSOCIATION, MENDELIAN RANDOMIZATION, MOLECULAR-GENETICS, RISK, SUBSTANCE USE DISORDERS, SUBTYPES, TRAITS, TRAJECTORIES |
| الوصف: | Attention-deficit/hyperactivity disorder (ADHD) is a severely impairing neurodevelopmental disorder with a prevalence of 5% in children and adolescents and of 2.5% in adults. Comorbid conditions in ADHD play a key role in symptom progression, disorder course and outcome. ADHD is associated with a significantly increased risk for substance use, abuse and dependence. ADHD and cannabis use are partly determined by genetic factors; the heritability of ADHD is estimated at 70–80% and of cannabis use initiation at 40–48%. In this study, we used summary statistics from the largest available meta-analyses of genome-wide association studies (GWAS) of ADHD (n = 53,293) and lifetime cannabis use (n = 32,330) to gain insights into the genetic overlap and causal relationship of these two traits. We estimated their genetic correlation to be r 2 = 0.29 (P = 1.63 × 10 −5 ) and identified four new genome-wide significant loci in a cross-trait analysis: two in a single variant association analysis (rs145108385, P = 3.30 × 10 −8 and rs4259397, P = 4.52 × 10 −8 ) and two in a gene-based association analysis (WDPCP, P = 9.67 × 10 −7 and ZNF251, P = 1.62 × 10 −6 ). Using a two-sample Mendelian randomization approach we found support that ADHD is causal for lifetime cannabis use, with an odds ratio of 7.9 for cannabis use in individuals with ADHD in comparison to individuals without ADHD (95% CI (3.72, 15.51), P = 5.88 × 10 −5 ). These results substantiate the temporal relationship between ADHD and future cannabis use and reinforce the need to consider substance misuse in the context of ADHD in clinical interventions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://pure.au.dk/portal/en/publications/ae05eedf-513a-41ef-9bf4-c519272e9215Test |
| DOI: | 10.1038/s41380-018-0339-3 |
| الإتاحة: | https://doi.org/10.1038/s41380-018-0339-3Test https://pure.au.dk/portal/en/publications/ae05eedf-513a-41ef-9bf4-c519272e9215Test http://www.scopus.com/inward/record.url?scp=85059569683&partnerID=8YFLogxKTest https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025199/pdf/nihms-1601935.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C837C498 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41380-018-0339-3 |
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