دورية أكاديمية
Systemic acute-phase response after laparoscopic and open cholecystectomy
| العنوان: | Systemic acute-phase response after laparoscopic and open cholecystectomy |
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| المؤلفون: | GRANDE, MICHELE, TUCCI, GIANFRANCO, RULLI, FRANCESCO, NERI, ANNA, FARINON, ATTILIO MARIA, Adorisio, O, Barini, A, Franchi, F |
| المساهمون: | Grande, M, Tucci, G, Adorisio, O, Barini, A, Rulli, F, Neri, A, Franchi, F, Farinon, Am |
| بيانات النشر: | SPRINGER-VERLAG NEW YORK |
| سنة النشر: | 2002 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | C reactive protein, cytokine, interleukin 1, interleukin 6, tumor necrosis factor, acute phase response, adult, aged, article, blood level, body temperature, cholecystectomy, clinical article, controlled study, cytokine production, female, hospitalization, human, inflammation, laparoscopic surgery, length of stay, leukocyte count, male, postoperative period, preoperative evaluation, priority journal, surgical technique, tissue injury, Acute-Phase Reaction, C-Reactive Protein |
| الوصف: | Background: Cytokines are the main mediators of inflammation and the response to trauma. The purpose of this study was to compare variations in cytokine levels following laparoscopic cholecystectomy (LC) and mini-laparotomy cholecystectomy (OC), since these two types of operations were considered to be a unique model for examining the role of local tissue injury in postoperative inflammatory reactions. Methods: A total of 40 patients were studied. Eighteen of them underwent LC; the remaining 22 were operated on using the open technique. Systemic concentrations of interleukin-6 (IL-6), interleukin-1 (IL-1), tumor necrosis factor (TNF), and C-reactive protein (CRP) were measured before and after the operation. In addition, we compared pre- and postoperative white blood cell (WBC) counts, postoperative body temperature, and length of postoperative hospitalization. Results: There was no difference between the two groups in IL-1 and TNF response. The rise in plasma IL-6 levels (18.86+/-9.61 vs 5.00+/-0.0 pg/ml, p<0.0001) and CRP (8.40&PLUSMN;5.81 vs 1.43&PLUSMN;1.30 mg/dl, p<0.001) were more marked after open cholecystectomy than after the laparoscopic procedure. There was no correlation between serum CRP concentrations and the other postoperative parameters. Conclusion: The magnitude of the acute-phase response was less pronounced following laparoscopic cholecystectomy, consistent with a reduction in tissue trauma. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000173599600019; volume:16; issue:2; firstpage:313; lastpage:316; journal:SURGICAL ENDOSCOPY; http://hdl.handle.net/2108/50117Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0036154066 |
| DOI: | 10.1007/s00464-001-9042-5 |
| الإتاحة: | https://doi.org/10.1007/s00464-001-9042-5Test http://hdl.handle.net/2108/50117Test |
| رقم الانضمام: | edsbas.C7A9EA2F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00464-001-9042-5 |
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