دورية أكاديمية
Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin
| العنوان: | Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin |
|---|---|
| المؤلفون: | Durak, Omer, Calderon de Anda, Froylan, Singh, Karuna K., Leussis, M. P., Petryshen, T. L., Sklar, P., Tsai, Li-Huei |
| المساهمون: | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Durak, Omer, Calderon de Anda, Froylan, Singh, Karuna K., Tsai, Li-Huei |
| المصدر: | PMC |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2014 |
| المجموعة: | DSpace@MIT (Massachusetts Institute of Technology) |
| الوصف: | Ankyrin-G is a scaffolding protein required for the formation of the axon initial segment in neurons. Recent genome-wide association studies and whole-exome sequencing have identified ANK3, the gene coding for ankyrin-G, to be a risk gene for multiple neuropsychiatric disorders, such as bipolar disorder, schizophrenia and autism spectrum disorder. Here, we describe a novel role for ankyrin-G in neural progenitor proliferation in the developing cortex. We found that ankyrin-G regulates canonical Wnt signaling by altering the subcellular localization and availability of β-catenin in proliferating cells. Ankyrin-G loss-of-function increases β-catenin levels in the nucleus, thereby promoting neural progenitor proliferation. Importantly, abnormalities in proliferation can be rescued by reducing Wnt pathway signaling. Taken together, these results suggest that ankyrin-G is required for proper brain development. ; Simons Foundation (Postdoctoral Fellowship) ; National Institutes of Health (U.S.) (Grant RO1 MH091115) ; Stanley Center for Psychiatric Research ; Howard Hughes Medical Institute |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1359-4184 1476-5578 |
| العلاقة: | http://dx.doi.org/10.1038/mp.2014.42Test; Molecular Psychiatry; http://hdl.handle.net/1721.1/102510Test; Durak, O, F C de Anda, K K Singh, M P Leussis, T L Petryshen, P Sklar, and L-H Tsai. “Ankyrin-G Regulates Neurogenesis and Wnt Signaling by Altering the Subcellular Localization of β-Catenin.” Mol Psychiatry 20, no. 3 (May 13, 2014): 388–397.; orcid:0000-0003-1262-0592; orcid:0000-0001-8426-6188 |
| الإتاحة: | https://doi.org/10.1038/mp.2014.42Test http://hdl.handle.net/1721.1/102510Test |
| حقوق: | Creative Commons Attribution-Noncommercial-Share Alike ; http://creativecommons.org/licenses/by-nc-sa/4.0Test/ |
| رقم الانضمام: | edsbas.C733A6AE |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 13594184 14765578 |
|---|