التفاصيل البيبلوغرافية
| العنوان: |
Abstract P140: The Association of Common Genetic Loci with Childhood Obesity in 1,612 Hispanic/Latino Children and Adolescents From Across the United States and Mexico |
| المؤلفون: |
Fernández-Rhodes, Lindsay, Graff, Mariaelisa, Bradfield, Jonathan, Wang, Yujie, Parra, Esteban J, Cruz, Miguel, Peralta-Romero, Jesús, Audirac-Chalifour, Astride, Hidalgo, Bertha, Highland, Heather, Comuzzie, Anthony G, Butte, Nancy F, Cole, Shelley A, Voruganti, V. S, Haiman, Christopher, Loos, Ruth F, North, Kari E |
| المصدر: |
Circulation ; volume 135, issue suppl_1 ; ISSN 0009-7322 1524-4539 |
| بيانات النشر: |
Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: |
2017 |
| الوصف: |
Childhood obesity is a global health concern due to its potential to increase cardiometabolic risk across the life course. In the United States (US) the burden of childhood obesity is highest among Hispanic/Latinos, in particular children or adolescents of Mexican descent. Although the genetic epidemiology of childhood obesity has been studied previously, the potential for novel childhood obesity loci in Hispanic/Latinos and the generalizability of previously reported loci to Hispanic/Latino children and adolescents are still unknown. Thus we aimed to conduct a genome-wide association study of childhood obesity in 1,612 Hispanic/Latino children and adolescents (2-18 years) collected as part of one Mexican (n=794 Mexico City Study) and two US (n=362 Children’s Hospital of Philadelphia; n=456 Viva La Familia Study) studies, and to generalize 11 previously reported childhood obesity loci from European descent samples to our Hispanic/Latino samples. Obesity cases and controls were defined by BMI-for-age percentiles based on the Centers for Disease Control and Prevention smoothed and sex-specific growth curves from 2000, wherein cases had percentiles ≥95 th and controls had percentiles ≤85 th . Each study performed a genome-wide logistic regression analysis of single nucleotide polymorphism (SNPs) after adjusting for sex, population stratification and relatedness, as applicable. We combined study results for SNPs >10 minor allele counts and imputation quality ≥0.5 using fixed-effect inverse-variance weighted meta-analysis. A priori, we estimated that in our sample (n effective =1,498) we would have >80% power to detect common SNPs (>15% minor allele frequency) across the genome (p<5x10 -8 ) that increase the odds of childhood obesity of 55% per risk allele. Generalizability at 11 known childhood obesity loci was defined as p<0.05 and directional consistency with the previously reported obesity-increasing allele. We found 5 suggestive childhood obesity loci (p<4x10 -6 ), including a SNP that ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1161/circ.135.suppl_1.p140 |
| الإتاحة: |
https://doi.org/10.1161/circ.135.suppl_1.p140Test |
| رقم الانضمام: |
edsbas.C679C9F3 |
| قاعدة البيانات: |
BASE |
