دورية أكاديمية
Head Down Tilt 15° in Acute Ischemic Stroke with Poor Collaterals: A Randomized Preclinical Trial
| العنوان: | Head Down Tilt 15° in Acute Ischemic Stroke with Poor Collaterals: A Randomized Preclinical Trial |
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| المؤلفون: | Mariani, Jacopo, Beretta, Simone, Diamanti, Susanna, Versace, Alessandro, Martini, Beatrice, Viganò, Martina, Castiglioni, Laura, Sironi, Luigi, Carone, Davide, Cuccione, Elisa, Monza, Laura, Giussani, Carlo, Ferrarese, Carlo |
| المساهمون: | J. Mariani, S. Beretta, S. Diamanti, A. Versace, B. Martini, M. Viganò, L. Castiglioni, L. Sironi, D. Carone, E. Cuccione, L. Monza, C. Giussani, C. Ferrarese |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | acute ischemic stroke, cerebral collateral, collateral therapeutic, head down tilt, ischemic penumbra, Settore BIO/14 - Farmacologia, Settore MED/26 - Neurologia |
| الوصف: | Cerebral collaterals are recruited after arterial occlusion with a protective effect on tissue outcome in acute ischemic stroke. Head down tilt 15 & DEG; (HDT15) is a simple, low cost and accessible procedure that could be applied as an emergency treatment, before recanalization therapies, with the aim to increase cerebral collateral flow. Spontaneously hypertensive rats have been shown to display anatomical differences in morphology and function of cerebral collaterals, compared to other rat strains, resulting in an overall poor collateral circulation. We investigate the efficacy and safety of HDT15 in spontaneously hypertensive (SHR) rats, which were considered as an animal stroke model with poor collaterals. Cerebral ischemia was induced by 90 minute endovascular occlu-sion of the middle cerebral artery (MCA). SHR rats were randomized to HDT15 or flat position (n = 19). HDT15 was applied 30 minutes after occlusion and lasted 60 minutes, until reperfusion. HDT15 application increased cerebral perfusion (+16.6% versus +6.1%; p = 0.0040) and resulted in a small reduction of infarct size (83.6 versus 107.1 mm3; -21.89%; p = 0.0272), but it was not associated with early neurological improvement, compared to flat position. Our study suggests that the response to HDT15 during MCA occlusion is dependent on baseline collaterals. Nonetheless, HDT15 promoted a mild improvement of cerebral hemodynamics even in subjects with poor collaterals, without safety concerns.& COPY; 2023 The Authors. Published by Elsevier Ltd on behalf of IBRO. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0Test/). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37211082; info:eu-repo/semantics/altIdentifier/wos/WOS:001013571700001; volume:523; firstpage:1; lastpage:6; numberofpages:6; journal:NEUROSCIENCE; https://hdl.handle.net/2434/1038629Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85160678360 |
| DOI: | 10.1016/j.neuroscience.2023.05.011 |
| الإتاحة: | https://doi.org/10.1016/j.neuroscience.2023.05.011Test https://hdl.handle.net/2434/1038629Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C679AF8C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.neuroscience.2023.05.011 |
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