دورية أكاديمية
Electrophysiological responses from vagus nerve stimulation in rats
| العنوان: | Electrophysiological responses from vagus nerve stimulation in rats |
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| المؤلفون: | Mollet, Lies, Raedt, Robrecht, Delbeke, Jean, EL TAHRY, RIEM, Grimonprez, Annelies, Dauwe, Ine, De Herdt, Veerle, Meurs, Alfred, Wadman, Wytse, Boon, Paul, Vonck, Kristl |
| المصدر: | INTERNATIONAL JOURNAL OF NEURAL SYSTEMS ; ISSN: 0129-0657 |
| سنة النشر: | 2013 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Biology and Life Sciences, PARAMETERS, nerve fiber type, laryngeal muscle potential, vagus nerve stimulation, CUFF ELECTRODE, PARTIAL SEIZURES, ELECTRICAL-STIMULATION, EPILEPTIC PATIENTS, LOCUS-COERULEUS, VAGAL-STIMULATION, vagus nerve recording, BRAIN, MODEL, SUPPRESSION |
| الوصف: | The mechanism of action of vagus nerve stimulation (VNS) for pharmacoresistant epilepsy is unknown and the therapeutic outcome is highly variable. We investigated stimulation-induced vagus nerve electrophysiological responses in rats using various stimulation parameters. Conduction velocity, I50, rheobase and chronaxie were calculated. We identified an early and late component corresponding to an afferent compound action potential (CAP) and a remote laryngeal motor-evoked potential (LMEP), respectively. The conduction velocity (CAP: 26.2 ± 1.4 m/s; LMEP: 32.4 ± 2.4 m/s) and I50 (CAP: 2.4 ± 0.3 mA; LMEP: 1.8±0.2 mA) were significantly different for both components, the rheobase (CAP: 140±30 μA; LMEP: 110±26 μA) and chronaxie (CAP: 66±7 μs; LMEP: 73±9 μs) were not. Using a pulse of 10 μs, the CAP saturated between 4-5 mA. Our method can be used to record VNS-induced electrophysiological responses in rats and provides an objective biomarker for electrical stimulation with various parameters in an experimental set-up. Our findings are potentially useful for clinical purposes in the sense that combination of VNS and recording of vagal nerve CAPs may help clinicians to determine the individual optimal intensity required to fully activate fast-conducting afferent fibers. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://biblio.ugent.be/publication/4140864Test; http://hdl.handle.net/1854/LU-4140864Test; http://dx.doi.org/10.1142/S0129065713500275Test; https://biblio.ugent.be/publication/4140864/file/4173063Test |
| DOI: | 10.1142/S0129065713500275 |
| الإتاحة: | https://doi.org/10.1142/S0129065713500275Test https://biblio.ugent.be/publication/4140864Test http://hdl.handle.net/1854/LU-4140864Test https://biblio.ugent.be/publication/4140864/file/4173063Test |
| حقوق: | No license (in copyright) ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.C5D13371 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1142/S0129065713500275 |
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